Evidence map›Paper›PMID 42079732›Full record

ArticlePeerJ2026

The modular chromosomal genomic plasticity mediating high level antibiotic resistance in eight clinical carbapenem-resistant

Shuai Wang, Xinrou Zheng, Xueyun Geng, Ling Li, Mingyu Wang

Abstract read
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In one paragraph

Article in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shuai Wang *State Key Laboratory of Microbial Technology, Shandong University, Qingdao, China.
Xinrou Zheng *State Key Laboratory of Microbial Technology, Shandong University, Qingdao, China.
Xueyun GengState Key Laboratory of Microbial Technology, Shandong University, Qingdao, China.
Ling LiState Key Laboratory of Microbial Technology, Shandong University, Qingdao, China.
Mingyu WangState Key Laboratory of Microbial Technology, Shandong University, Qingdao, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Methods: Nanopore whole-genomic sequencing was performed and compared with carbapenem-susceptible Results: Although some of these strains contain transferable plasmids, 121 of 122 antibiotic resistance genes (ARGs) identified are located on their chromosomes. Moreover, chromosomal ARGs clustered within recombinase-rich regions forming clear modules that are different from known resistance genomic islands. These modules are tandemly linked forming different combinations, and integrated at specific hot-spots Conclusions: We find that modular chromosomal plasticity is the primary driver of carbapenem-resistance in our collection of CRAB isolates, which is a unique evolutionary strategy different from other ESKAPE pathogens. This study provides critical insights into CRAB genomic adaptability, and informs future strategies to combat their spread.

Indexed as

Acinetobacter baumanniiAnti-Bacterial AgentsCarbapenemsChromosomes, BacterialDrug Resistance, Multiple, BacterialGenome, BacterialAcinetobacter InfectionsGenomic IslandsHumansMicrobial Sensitivity TestsPlasmidsAnti-Bacterial AgentsCarbapenemsAcinetobacter baumanniiCarbapenem resistanceGenomic plasticityMultidrug resistancePlasmidWhole genome sequencing

Identifiers

PMID42079732
PMCPMC13134544

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.