Evidence map›Paper›PMID 42079714›Full record

ArticlePeerJ2026

The oral maternal microbiome plays a role in the development of cleft lip and palate condition in children.

Suzana Eiko Sato Guima, Bárbara Bischain, Lívia C Morais Gama, Agatha Cristhina Faria, Talita Lourenço, Daniela Franco Bueno, Debora Heller, Maria Rita Passos-Bueno, João C Setubal

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Suzana Eiko Sato GuimaDepartamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil.
Bárbara BischainCentro de Estudos do Genoma Humano, Departamento de Genética e Biologia Evolutiva, Instituto de Biociências, Universidade de São Paulo, São Paulo, Brazil.
Lívia C Morais GamaDepartamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil.
Agatha Cristhina FariaCentro de Estudos do Genoma Humano, Departamento de Genética e Biologia Evolutiva, Instituto de Biociências, Universidade de São Paulo, São Paulo, Brazil.
Talita LourençoInstituto de Microbiologia Paulo de Góes, Departamento de Microbiologia Médica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Daniela Franco BuenoAlbert Einstein Israeli College of Health Sciences, Albert Einstein Hospital, São Paulo, Brazil.
Debora HellerUT Health San Antonio, University of Texas, San Antonio, TX, United States of America.
Maria Rita Passos-BuenoCentro de Estudos do Genoma Humano, Departamento de Genética e Biologia Evolutiva, Instituto de Biociências, Universidade de São Paulo, São Paulo, Brazil.
João C SetubalDepartamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-syndromic cleft lip or palate (NS-CL/P) is an oral birth defect with complex aetiology. We compared the microbial diversity and composition of the oral microbiome of mothers of babies with NS-CL/P (CLP group) and mothers of babies without NS-CL/P (control group). Oral microbiome composition was determined by sequencing the V3-V4 regions of the 16S rRNA gene. CLP and control groups had overall similar microbial compositions, but significant differences were observed. The most significant microbial genus related to these differences was

Indexed as

Cleft LipCleft PalateMicrobiotaMouthFemaleHumansMaleMothersRNA, Ribosomal, 16SRNA, Ribosomal, 16SCutibacteriumLimosilactobacillusMale babiesMaternal oral microbiomeMicrobiomeNon-syndromic cleft lip or palaterRNA 16S unit

Identifiers

PMID42079714
PMCPMC13131353

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.