Evidence map›Paper›PMID 42079675›Full record

Observational studyResearch and practice in thrombosis and haemostasis2026

Prescribing patterns and clinician preferences for direct oral anticoagulant use in unusual site venous thromboembolism: a cross-sectional analysis from the Direct oral anticoagulants in Unusual Site venous Thromboembolism (DUST) study.

Nicoletta Riva, Laurent Bertoletti, Antonio Chistolini, Valerio De Stefano, Sofia Barbar, Marco Paolo Donadini, Maria Teresa Sartori, Francis Couturaud, Michelangelo Sartori, Alexander Gatt and 15 more

Registry-linked trialAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Research and practice in thrombosis and haemostasis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03778502 (International Registry on the Use of the Direct Oral Anticoagulants for the Treatment of Unusual Site Venous Thromboembolism), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03778502 completednot on this map

International Registry on the Use of the Direct Oral Anticoagulants for the Treatment of Unusual Site Venous Thromboembolism

Typeobservational_patient_registrySponsorUniversity of MaltaRan2019 to 2024Enrolled358ConditionsSplanchnic Vein Thrombosis, Cerebral Vein Thrombosis, Ovarian Vein Thrombosis, Renal Vein ThrombosisArmsDirect Oral Anticoagulants
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Renal Vein Thrombosis: A Narrative Review.Diagnostics (Basel, Switzerland) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Nicoletta RivaDepartment of Pathology, Faculty of Medicine and Surgery, University of Malta, Msida, Malta.
Laurent BertolettiUniversité Jean Monnet Saint-Étienne, Centre Hospitalier Universitaire Saint-Étienne, Mines Saint-Etienne, Institut National de la Santé et de la Recherche Médicale, SAnté INgéniérie BIOlogie St-Etienne U1059, Centre d'Investigation Clinique 1408, Département de Médecine Vasculaire et Thérapeutique, all in F-42055, Saint-Etienne, France.
Antonio ChistoliniDipartimento di Medicina Traslazionale e di Precisione, Sapienza Università di Roma, Rome, Italy.
Valerio De StefanoSection of Hematology, Department of Radiological and Hematological Sciences, Catholic University, Fondazione Policlinico Gemelli Istituto di Ricovero e Cura a Caracterere Scientifico, Rome, Italy.
Sofia BarbarDipartimento di Area Medica, Unità Operativa Semplice Dipartimentale Malattie Trombotico-Emorragiche, P.O. Cittadella, ULSS6 Euganea, Cittadella, Padua, Italy.
Marco Paolo DonadiniResearch Center on Thromboembolic Disorders and Antithrombotic Therapies, Department of Medicine and Surgery, University of Insubria-Azienda Socio-Sanitaria Territoriale Sette Laghi, Varese, Italy.
Maria Teresa SartoriClinical Medicine 1, Department of Medicine, University Hospital of Padua, Padua, Italy.
Francis CouturaudFrench Clinical Research Infrastructure Network Investigation Network On Venous Thrombo-Embolism network, Saint-Etienne, France.
Michelangelo SartoriAngiology and Blood Coagulation Unit, Istituto di Ricovero e Cura a Caracterere Scientifico Azienda Ospedaliero-Universitaria, Bologna, Italy.
Alexander GattDepartment of Pathology, Faculty of Medicine and Surgery, University of Malta, Msida, Malta.
Omri CohenDepartment of Transfusion Medicine, Kaplan Medical Center and The Hebrew University of Jerusalem, Jerusalem, Israel.
Chiara FantoniDepartment of Internal Medicine, Ospedale Maggiore, Bologna, Italy.
Scott KaatzHenry Ford Health System, Detroit, Michigan, USA.
Alenka MavriDepartment of Vascular Diseases, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Isabelle MahéFrench Clinical Research Infrastructure Network Investigation Network On Venous Thrombo-Embolism network, Saint-Etienne, France.
Judith CatellaFrench Clinical Research Infrastructure Network Investigation Network On Venous Thrombo-Embolism network, Saint-Etienne, France.
Pedro Ruiz-ArtachoInternal Medicine Department, Clinica Universidad de Navarra, Madrid, Spain.
Giorgio GhigliottiU.O. Clinica di Malattie dell'Apparato Cardiovascolare, Istituto di Ricovero e Cura a Caracterere Scientifico Ospedale Policlinico San Martino, Genova, Italy.
Luis Jara-PalomaresRespiratory Department, Virgen del Rocío Hospital and Instituto de Biomedicina, Sevilla, Spain.
Gian Marco PoddaMedicina Generale 2, Azienda Socio-Sanitaria Territoriale Santi Paolo e Carlo, Università degli Studi di Milano, Milan, Italy.
Alessandro SquizzatoResearch Center on Thromboembolic Disorders and Antithrombotic Therapies, Department of Medicine and Surgery, University of Insubria-ASST Lariana, Como, Italy.
Ponlapat RojnuckarinKing Chulalongkorn Memorial Hospital, Chulalongkorn University, Bangkok, Thailand.
Jenneke LeentjensDepartment of Internal Medicine Radboud Institute of Health Sciences, Radboud University Medical Center Nijmegen, Nijmegen, the Netherlands.
Marie Antoinette SevestreFrench Clinical Research Infrastructure Network Investigation Network On Venous Thrombo-Embolism network, Saint-Etienne, France.
Walter AgenoDepartment of Medicine, University of Padua, Padua, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Unusual site venous thromboembolism (USVTE) presents therapeutic challenges. Direct oral anticoagulants (DOACs) are increasingly prescribed despite limited evidence from clinical trials. Objectives: This cross-sectional analysis aimed to describe DOAC prescription patterns and rationale for choosing DOACs for USVTE treatment in real-life clinical practice. Methods: The Direct oral anticoagulants in Unusual Site venous Thromboembolism study (NCT03778502) is an international, multicenter, prospective, observational registry. Adult patients with objectively diagnosed USVTE (years 2018-2023) treated with DOACs were included. Information was collected on patient characteristics, USVTE location, anticoagulant treatment, and rationale for starting DOACs. Results: In total, 349 patients were included from 23 centers in 9 countries. The most common USVTE were splanchnic vein thrombosis ( Conclusion: DOACs are increasingly prescribed for USVTE owing to their ease of use and perceived safety, but mainly after initial treatment with parenteral anticoagulation. Further evidence is still needed to support their use in the acute phase.

Indexed as

AnticoagulantsFactor Xa InhibitorsPractice Patterns, Physicians'Venous ThromboembolismVenous ThrombosisAdministration, OralAdultAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedProspective StudiesPyrazolesPyridonesAnticoagulantsapixabanFactor Xa InhibitorsPyrazolesPyridonesRivaroxabancerebral veinsdirect-acting oral anticoagulantportal veinsplanchnic circulationvenous thromboembolism

Identifiers

PMID42079675
PMCPMC13129430

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.