Evidence map›Paper›PMID 42079633›Full record

ArticleFrontiers in immunology2026

SIRL-1 deficiency reveals pro-inflammatory IL-8 axis in inflammatory bowel disease: a novel diagnostic ratio.

Zhengzheng Wang, Shan Li, Qi Tan, Jianmin Sang, Zhen Xu, Xuewei Ding, Xiaoyan Yao, Nianzhen Chen, Shanshan Yu, Ming Zong and 3 more

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In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Zhengzheng Wang *School of Medicine, Tongji University, Shanghai, China.
Shan Li *School of Medicine, Tongji University, Shanghai, China.
Qi TanDepartment of Laboratory Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Jianmin SangSchool of Medicine, Tongji University, Shanghai, China.
Zhen XuSchool of Medicine, Tongji University, Shanghai, China.
Xuewei DingSchool of Medicine, Tongji University, Shanghai, China.
Xiaoyan YaoSchool of Medicine, Tongji University, Shanghai, China.
Nianzhen ChenDepartment of Laboratory Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Shanshan YuDepartment of Laboratory Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Ming ZongDepartment of Laboratory Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Ying LuResearch Center for Translational Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Lan ZhongSchool of Medicine, Tongji University, Shanghai, China.
Lieying FanSchool of Medicine, Tongji University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Inflammatory Bowel Disease (IBD), including Ulcerative Colitis and Crohn's Disease, is characterized by chronic intestinal inflammation, neutrophil infiltration and elevated pro-inflammatory cytokines like Interleukin-8 (IL-8). While pro-inflammatory mechanisms are well-studied, the contribution of intrinsic inhibitory immune checkpoints to IBD pathogenesis is less understood. This study aimed to assess the expression and function of Signal Inhibitory Receptor on Leukocytes-1 (SIRL-1) in IBD and to evaluate the diagnostic utility of the SIRL-1/IL-8 ratio. Methods: Peripheral venous blood was collected from 90 participants (IBD patients and healthy volunteers). Neutrophil SIRL-1 protein expression was quantified by flow cytometry, while Results: IBD patients exhibited significant downregulation of SIRL-1 protein and Conclusions: Deficiency in SIRL-1 appears to be a permissive factor for the pro-inflammatory IL-8 axis in IBD. The SIRL-1/IL-8 ratio represents a promising novel diagnostic biomarker that presents enhanced precision by reflecting the imbalance between immune regulation and inflammation. Notably, this ratio revealed superior diagnostic value in Crohn's Disease despite the lack of significant IL-8 elevation, highlighting its utility in capturing intrinsic immune defects.

Indexed as

Inflammatory Bowel DiseasesInterleukin-8AdultBiomarkersColitis, UlcerativeCrohn DiseaseFemaleHumansMaleMiddle AgedNeutrophilsROC CurveYoung AdultBiomarkersCXCL8 protein, humanInterleukin-8biomarkerCrohn’s diseaseinflammationinflammatory bowel diseaseinterleukin-8SIRL-1ulcerative colitis

Identifiers

PMID42079633
PMCPMC13132746

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.