Evidence map›Paper›PMID 42079629›Full record

ArticleFrontiers in immunology2026

Neutrophil extracellular traps formation is associated with impaired clot retraction and fibrinolysis in asthma.

Tomasz Misztal, Maria Magdalena Tomasiak-Łozowska, Aleksandra Poznalska, Wiktoria Ciochanowska, Tomasz Rusak, Marcin Moniuszko

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Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Tomasz Misztal *Department of Physical Chemistry, Medical University of Białystok, Białystok, Poland.
Maria Magdalena Tomasiak-Łozowska *Department of Allergy and Internal Diseases, Medical University of Białystok, Białystok, Poland.
Aleksandra PoznalskaStudent Science Club in the Department of Allergy and Internal Diseases, Medical University of Białystok, Białystok, Poland.
Wiktoria CiochanowskaStudent Science Club in the Department of Allergy and Internal Diseases, Medical University of Białystok, Białystok, Poland.
Tomasz RusakDepartment of Physical Chemistry, Medical University of Białystok, Białystok, Poland.
Marcin MoniuszkoDepartment of Allergy and Internal Diseases, Medical University of Białystok, Białystok, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Asthma is associated with an elevated risk of venous thromboembolism and pulmonary embolism; its etiology is not completely understood. Objective: This study was designed to investigate whether the formation of neutrophil extracellular traps (NET) is associated with impaired clot retraction and fibrinolysis in the blood of patients with asthma. Methods: Groups of 50 patients with asthma and 40 healthy subjects were enrolled in this study. Clot retraction kinetics were assessed by optical method (using a digital camera); fibrinolysis was recorded by thromboelastometry; NET predictors in plasma or serum-citrullinated histone H3 concentration, myeloperoxidase activity, and cell-free DNA level-were measured by microplate immunoenzymatic, colorimetric, and fluorometric assays, respectively. Spirometry (FEV Results: We found the elevated NET predictors in the blood of patients with asthma, which notably correlate with significant inhibition of clot retraction and fibrinolysis compared to the control group. FENO was found to be the most closely correlated with impaired fibrinolysis and clot retraction among all clinical tests. Conclusion: It was concluded that the formation of NET in the blood of patients with asthma is associated with impairment of clot retraction and fibrinolysis, which may contribute to the formation of unstable thrombi. This may partially explain the elevated risk of venous thromboembolism and pulmonary embolism in asthma.

Indexed as

AsthmaBlood CoagulationExtracellular TrapsFibrinolysisNeutrophilsThrombosisAdultBiomarkersFemaleHumansMaleMiddle AgedNitric OxideThrombelastographyBiomarkersNitric Oxideasthmaclot retractionfibrinolysishistone H3myeloperoxidaseneutrophil extracellular trapsneutrophilic asthmathromboembolism

Identifiers

PMID42079629
PMCPMC13132744

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.