Evidence map›Paper›PMID 42079628›Full record

ArticleFrontiers in immunology2026

The relationship between obesity and disease relapse in systemic lupus erythematosus: a retrospective cohort study using the LUNA registry.

Naoki Suzuki, Ryusuke Yoshimi, Hiroki Mizuno, Chiharu Hidekawa, Natsuki Sakurai, Yuji Yoshioka, Daiga Kishimoto, Kaoru Takase-Minegishi, Shigeru Ohno, Nobuyuki Yajima and 21 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Naoki SuzukiDepartment of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Ryusuke YoshimiDepartment of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Hiroki MizunoDepartment of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Chiharu HidekawaDepartment of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Natsuki SakuraiDepartment of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Yuji YoshiokaDepartment of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Daiga KishimotoDepartment of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Kaoru Takase-MinegishiDepartment of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Shigeru OhnoCenter for Rheumatic Diseases, Yokohama City University Medical Center, Yokohama, Japan.
Nobuyuki YajimaDivision of Rheumatology, Department of Medicine, Showa Medical University, Tokyo, Japan.
Ken-Ei SadaDepartment of Clinical Epidemiology, Kochi Medical School, Kochi University, Nankoku, Japan.
Yoshia MiyawakiDepartment of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Kunihiro IchinoseDepartment of Rheumatology, Shimane University Faculty of Medicine, Izumo, Japan.
Toshimasa ShimizuDepartment of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Ayuko TakataniDepartment of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Hiroshi KajiyamaDepartment of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan.
Shuzo SatoDepartment of Rheumatology, Fukushima Medical University School of Medicine, Fukushima, Japan.
Yasuhiro ShimojimaDepartment of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Matsumoto, Japan.
Michio FujiwaraDepartment of Rheumatology, Yokohama Rosai Hospital, Yokohama, Japan.
Akira OnishiDepartment of Advanced Medicine for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Takashi KidaInflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Yusuke MatsuoDepartment of Rheumatology, Tokyo Kyosai Hospital, Tokyo, Japan.
Keisuke NishimuraDepartment of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan.
Takahisa OnishiDepartment of Rheumatology, Kakogawa Central City Hospital, Kakogawa, Japan.
Masao KatsushimaDepartment of Clinical Immunology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
Kunihiko UmekitaDivision of Respirology, Rheumatology, Infectious Diseases, and Neurology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Hirofumi MiyakeDepartment of General Internal Medicine, Tenri Hospital, Tenri, Japan.
Hiroto NakanoDepartment of Rheumatology, Yokohama Minami Kyosai Hospital, Yokohama, Japan.
Tomoaki IdaDepartment of Allergy and Clinical Immunology, Chiba University Hospital, Chiba, Japan.
Kei IkedaDepartment of Rheumatology, Dokkyo Medical University, Tochigi, Japan.
Hideaki NakajimaDepartment of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Recent reports have suggested an association between the pathogenesis of systemic lupus erythematosus (SLE) and various adipokines secreted by adipocytes. However, the impact of obesity on the susceptibility to SLE relapses remains unclear. This study investigated the association between obesity and relapse in patients with SLE using a large, multicenter cohort. Methods: Patients enrolled in LUNA, a nationwide, multicenter SLE registry in Japan, with a body mass index (BMI) ≥ 18.5 kg/m Results: Among the 1, 134 patients, 909 were classified as normal weight and 225 as obese. The multivariate analysis showed that obesity significantly reduced relapse rates (odds ratio [OR] 0.52, 95% confidence interval [CI] 0.30-0.90, Conclusion: Patients with mild obesity had lower relapse rates than those with normal BMI. The findings suggest that metabolic status may influence the disease course of SLE. Appropriate weight management guidance, including avoiding excessive dietary restriction, may help prevent SLE relapses.

Indexed as

Lupus Erythematosus, SystemicObesityAdultBody Mass IndexFemaleHumansJapanMaleMiddle AgedRecurrenceRegistriesRetrospective StudiesRisk FactorsLUNA registryobesityoverweightrelapseremissionsystemic lupus erythematosus

Identifiers

PMID42079628
PMCPMC13128556

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.