Evidence map›Paper›PMID 42079623›Full record

ArticleFrontiers in immunology2026

The CXCL9/SPP1 polarity axis in tumor-associated macrophages: immunoregulatory and prognostic significance in non-small cell lung cancer.

Houqiang Li, Miaoyan Liu, Shenghan Xu, Yike Zhou, Youlang Zhou, Jiahai Shi, Lou Zhong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Houqiang Li *Department of Thoracic Surgery, Affiliated Hospital of Nantong University, Nantong, China.
Miaoyan Liu *Department of Thoracic Surgery, Affiliated Hospital of Nantong University, Nantong, China.
Shenghan XuDepartment of Thoracic Surgery, Affiliated Hospital of Nantong University, Nantong, China.
Yike ZhouDepartment of Thoracic Surgery, Affiliated Hospital of Nantong University, Nantong, China.
Youlang ZhouResearch Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong, China.
Jiahai ShiDepartment of Thoracic Surgery, Affiliated Hospital of Nantong University, Nantong, China.
Lou ZhongDepartment of Thoracic Surgery, Affiliated Hospital of Nantong University, Nantong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study addresses the limitations of the traditional M1/M2 binary classification for tumor-associated macrophages (TAMs) in non-small cell lung cancer (NSCLC) by introducing a NSCLC-specific functional framework based on the

Indexed as

Carcinoma, Non-Small-Cell LungChemokine CXCL9Lung NeoplasmsOsteopontinTumor-Associated MacrophagesBiomarkers, TumorCell PolarityFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansPrognosisTumor MicroenvironmentBiomarkers, TumorChemokine CXCL9CXCL9 protein, humanOsteopontinCXCL9/SPP1 polarity axismacrophage polarizationnon-small cell lung cancer (NSCLC)prognosistumor-associated macrophages (TAMs)tumor microenvironment (TME)

Identifiers

PMID42079623
PMCPMC13132838

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.