Evidence map›Paper›PMID 42079615›Full record

ArticleFrontiers in immunology2026

Predicting immune reconstitution after antiretroviral therapy in HIV/AIDS using ensemble machine learning: a real-world study.

Juan Jin, Tingting Li, Jie Chen, Huanhuan Ba, Yuan Zhang, Jiajia Li, Jinling Yin, Huanqing Liu, Kangxiao Ma

Abstract read
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Juan JinDepartment of Infectious Diseases, The Eighth's Hospital of Xi'an, Xi'an, Shaanxi, China.
Tingting LiDrug Clinical Trial Institution Office, Xi'an Chest Hospital, Xi'an, Shaanxi, China.
Jie ChenDepartment of Infectious Diseases, The Eighth's Hospital of Xi'an, Xi'an, Shaanxi, China.
Huanhuan BaDepartment of Infectious Diseases, The Eighth's Hospital of Xi'an, Xi'an, Shaanxi, China.
Yuan ZhangDepartment of Infectious Diseases, The Eighth's Hospital of Xi'an, Xi'an, Shaanxi, China.
Jiajia LiDepartment of Infectious Diseases, The Eighth's Hospital of Xi'an, Xi'an, Shaanxi, China.
Jinling YinDepartment of Infectious Diseases, The Eighth's Hospital of Xi'an, Xi'an, Shaanxi, China.
Huanqing LiuInformation Management Office, Northwestern Polytechnical University, Xi'an, Shaanxi, China.
Kangxiao MaDepartment of Infectious Diseases, The Eighth's Hospital of Xi'an, Xi'an, Shaanxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Accurate prediction of long-term CD4 Methods: We developed a heterogeneous stacking ensemble framework to predict longitudinal CD4 Results: On an independent test set (n=1,088), the ensemble achieved an R Conclusion: Our ensemble learning framework provides a robust and clinically applicable tool for forecasting multi-dimensional immune reconstitution in HIV care. By synthesizing diverse algorithmic perspectives without relying on baseline immunology, it offers a foundation for data-driven clinical decision support to personalize long-term treatment monitoring.

Indexed as

Anti-HIV AgentsHIV InfectionsImmune ReconstitutionMachine LearningAdultAntiretroviral Therapy, Highly ActiveBoosting Machine Learning AlgorithmsCD4-CD8 RatioCD4 Lymphocyte CountClassification AlgorithmsFemaleHumansMalePrediction AlgorithmsPredictive Learning ModelsRandom ForestAnti-HIV Agentsantiretroviral therapyCD4 recoveryensemble learningHIV/AIDSimmunological forecastingmachine learningpredictive modelling

Identifiers

PMID42079615
PMCPMC13128594

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.