Evidence map›Paper›PMID 42079600›Full record

ArticleFrontiers in immunology2026

Chris Marco Nana Mbianda, Bodin Darcisse Kwanou Tchakounte, Bernard Marie Bitye Zambo, Joséphine Ntankheuh Tchinkou, Derrick Atchombat Nyasse, Balotin Fogang, Rafael José Argüello, Lawrence Ayong, Rosette Megnekou

Abstract read
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In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chris Marco Nana MbiandaDepartment of Animal Biology and Physiology, Faculty of Sciences, University of Yaoundé I, Yaoundé, Cameroon.
Bodin Darcisse Kwanou TchakounteDepartment of Animal Biology and Physiology, Faculty of Sciences, University of Yaoundé I, Yaoundé, Cameroon.
Bernard Marie Bitye ZamboDepartment of Animal Biology and Physiology, Faculty of Sciences, University of Yaoundé I, Yaoundé, Cameroon.
Joséphine Ntankheuh TchinkouImmunology Laboratory of the Biotechnology Center, University of Yaoundé I, Yaoundé, Cameroon.
Derrick Atchombat NyasseDepartment of Animal Biology and Physiology, Faculty of Sciences, University of Yaoundé I, Yaoundé, Cameroon.
Balotin FogangMalaria Research Unit, Centre Pasteur du Cameroun, Yaoundé, Cameroon.
Rafael José ArgüelloAix-Marseille University, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille, Marseille, France.
Lawrence AyongMalaria Research Unit, Centre Pasteur du Cameroun, Yaoundé, Cameroon.
Rosette MegnekouDepartment of Animal Biology and Physiology, Faculty of Sciences, University of Yaoundé I, Yaoundé, Cameroon.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: γδ T cells play a key role in modulating immune responses to pregnancy-associated malaria and can enhance vaccine efficacy through their activation and cytotoxic functions. However, the mechanisms guiding γδT cell differentiation in placental malaria (PM) remain poorly understood. We examined Methods: A case-control study including 50 women at delivery (21 PM+, 29 PM-) was carried out. Peripheral, placental intervillous space, and cord blood mononuclear cells were isolated, and multiparametric flow cytometry was performed to characterize γδT-cells and memory phenotypes, its subsets (Vδ1 Results: In general, the frequency of γδ T cells and their subsets varied depending on the different blood compartments, with naïve and central memory (CM) phenotypes observed mainly in CBMC, while effector memory (EM) and terminally differentiated effector memory (TEMRA) phenotypes were found mainly in PBMC and IVBMC. Conclusion: Placental malaria is associated with a compartment-specific memory γδ T cell differentiation, with cytokines and metabolic reprogramming regulating exhaustion. These findings reveal key regulatory processes that determine the function of γδ T cells during placental malaria, which constitute potential targets for new therapeutic intervention against PM.

Indexed as

CytokinesIntraepithelial LymphocytesMalaria, FalciparumPlacentaPlasmodium falciparumPregnancy Complications, ParasiticReceptors, Antigen, T-Cell, gamma-deltaAdultCase-Control StudiesCell DifferentiationFemaleHumansImmunologic MemoryLymphocyte ActivationMetabolic ReprogrammingPregnancyCytokinesReceptors, Antigen, T-Cell, gamma-deltacytokinesmetabolic reprogrammingplacental malariaPlasmodium falciparumγδT cells memory

Identifiers

PMID42079600
PMCPMC13128425

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.