Evidence map›Paper›PMID 42079595›Full record

ArticleFrontiers in immunology2026

Single-cell RNA sequencing of leukocytes at the maternal-fetal interface in physiological and pathological Nodal-deficient pregnancies.

Sarah Yull, Alain Pacis, Laura Girardet, Daniel Dufort

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Spleen-associated macrophage alterations and embryo viability in a murine model of recurrent spontaneous abortion.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sarah YullDivision of Experimental Medicine, McGill University, Montréal, QC, Canada.
Alain PacisCanadian Centre for Computational Genomics, McGill University, Montréal, QC, Canada.
Laura GirardetChild Health and Human Development Program, Research Institute of the McGill University Health Centre, Montréal, QC, Canada.
Daniel DufortDivision of Experimental Medicine, McGill University, Montréal, QC, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Leukocytes at the maternal-fetal interface have critical functions during pregnancy in the prevention of maternal reactivity towards fetal alloantigens, suppression of excess inflammation and promotion of placental angiogenesis. Failed maternal immune adaptations to pregnancy can lead to placental insufficiency and the development of severe reproductive complications. Recent evidence from mouse models has suggested that Nodal, a secreted morphogen of the TGFβ superfamily, is an immunoregulator of pregnancy. The absence of Nodal expression in the female reproductive tract (Nodal

Indexed as

LeukocytesMaternal-Fetal ExchangeNodal ProteinPlacentaAnimalsDeciduaFemaleHumansMiceMice, KnockoutPregnancySingle-Cell AnalysisSingle-Cell Gene Expression AnalysisNodal Proteinfetal lossintrauterine growth restrictionmacrophageneutrophilNodalpregnancyreproductive failuresingle cell RNA sequencing

Identifiers

PMID42079595
PMCPMC13130886

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.