ArticleFrontiers in immunology2026
Case Report: Complete metabolic responses to trastuzumab-deruxtecan in HER2-altered solid tumors: two illustrative cases.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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10 authors.
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Abstract
Background: Human epidermal growth factor receptor-2 (HER2) alterations, including activating mutations and gene amplification, are emerging therapeutic targets in several solid tumors. Trastuzumab-deruxtecan (T-DXd), a HER2-directed antibody-drug conjugate (ADC), has demonstrated antitumor activity across multiple HER2-altered cancers. However, complete metabolic responses (CMRs) remain uncommon, particularly when assessed by 2-deoxy-2-[18F] fluoro-D-glucose positron emission tomography-computed tomography (FDG-PET/CT). Presentation of cases: We report two patients with metastatic HER2-driven malignancies who achieved a CMR under T-DXd. The first case concerns a patient with metastatic non-small cell lung cancer harboring a HER2 exon 20 insertion who progressed on chemoimmunotherapy and HER2-directed antibodies. Third-line T-DXd led to rapid metabolic improvement and complete resolution of all lesions, including a brain metastasis. The second case involves a patient with metastatic micropapillary urothelial carcinoma with HER2 expression, refractory to platinum chemotherapy, avelumab maintenance, and enfortumab vedotin. T-DXd induced an early partial metabolic response (PMR), followed by a confirmed CMR after four cycles. Conclusion: These two observations illustrate the capacity of T-DXd to induce deep and complete metabolic remissions in distinct HER2-altered solid tumors. They support further development of HER2-targeted ADCs beyond traditional indications and highlight the value of FDG-PET/CT for assessing the depth of response to these agents.
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