ReviewFrontiers in immunology2026
The S100A8/A9-NETosis feedback loop in sepsis: potential mechanisms, immune crosstalk, and therapeutic targeting.
Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Article
- Targeting neutrophil extracellular traps in bacterial infections: mechanistic insights and translational perspectives.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis has a high incidence and mortality rate, bringing about a high global burden. Recent research has demonstrated that the S100A8/A9-NETosis feedback loop is considered a central regulator of sepsis. However, few studies have integrated these elements into a unified 'S100A8/A9-NETosis feedback loop'. Meanwhile, a systematic description of this loop in the interaction between myeloid cells and platelets, as well as organ damage, has not been established. This review systematically proposes the S100A8/A9-NETosis positive feedback loop as a core pathological mechanism and explores its potential pathways in sepsis. Specifically, we examine how this loop drives neutrophil-mediated hyperinflammation, monocyte/macrophage polarization, immune paralysis (mediated by dendritic cells and myeloid-derived suppressor cells), and immune thrombosis (triggered by platelets). We also evaluate how this loop contributes to organ-specific injury and discuss potential therapeutic strategies, providing new perspectives for sepsis treatment.
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Registered trials
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