Evidence map›Paper›PMID 42079570›Full record

ArticleFrontiers in immunology2026

Spatial transcriptomics identifies fibroblast-T cell crosstalk as a driver of Th2 polarization in allergic rhinitis.

Miao Zhao, Jiaqi Duan, Yongmin Xie, Guan Huang, Gui Yang, Pingchang Yang, Haotao Zeng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Miao Zhao *Department of Clinical Chemistry, Longgang ENT Hospital, Shenzhen ENT Institute and Shenzhen Key Laboratory of ENT, Shenzhen, China.
Jiaqi Duan *Department of Otolaryngology, Longgang Central Hospital, Shenzhen, China.
Yongmin XieDepartment of Otolaryngology, Longgang Central Hospital, Shenzhen, China.
Guan HuangDepartment of Otolaryngology, Longgang Central Hospital, Shenzhen, China.
Gui YangDepartment of Otolaryngology, Longgang Central Hospital, Shenzhen, China.
Pingchang YangState Key Laboratory of Respiratory Diseases, Allergy Division at Shenzhen University, Institute of Allergy and Immunology of Shenzhen University, Shenzhen Key Laboratory of Allergy and Immunology, Shenzhen, China.
Haotao ZengDepartment of Clinical Chemistry, Longgang ENT Hospital, Shenzhen ENT Institute and Shenzhen Key Laboratory of ENT, Shenzhen, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Allergic rhinitis (AR) is a common chronic nasal mucosal inflammatory disorder driven by type 2 immunity, but the spatial stromal-immune cell interactions underlying its pathogenesis remain unclear. Methods: We used 10x Genomics Xenium Results: Nine major cell types with tissue-specific localization were identified. The AR samples showed expanded fibroblast-rich regions (34.2 ± 3.1% vs. 15.6 ± 2.4% in controls; Conclusions: AR is defined by expanded fibroblast niches, fibroblast-derived type 2 mediators, and ligand-receptor-dependent fibroblast-Th2 crosstalk-a central pathogenic driver and potential therapeutic target.

Indexed as

Cell CommunicationFibroblastsRhinitis, AllergicTh2 CellsAdultFemaleGene Expression ProfilingHumansMaleMiddle AgedNasal MucosaSpatial Transcriptomicsallergyfibroblastnasal mucosaspatial transcriptomicsT cellXenium In Situ

Identifiers

PMID42079570
PMCPMC13133560

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.