Evidence map›Paper›PMID 42079342›Full record

ArticleJournal of cancer prevention2026

Oral Administration of Withaferin A Increases Infiltration of CD4

Eun-Ryeong Hahm, Krishna B Singh, Shivendra V Singh

Abstract read
In one paragraph

Article in Journal of cancer prevention, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Eun-Ryeong HahmDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0002-3197-4575
Krishna B SinghDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0002-4052-4373
Shivendra V SinghDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0002-3733-144X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Withaferin A (WA) is a small molecule present in Ashwagandha plant that prevents breast cancer progression in mice and rats. The mechanisms underlying breast cancer prevention by WA are not fully understood. Herein, we report effects of WA treatment on an immune landscape in C3(1)-TAg transgenic mice, which develop basal-like breast cancer. Oral administration of 12 mg/kg body weight of WA decreased the wet tumor weight by about 43%. Weight loss or any other adverse effects (e.g., impaired movement, hunched back, ruffled fur, etc.) were not observed. Tumors and splenocytes from WA-treated mice exhibited the increased proportion of CD4

Indexed as

Breast neoplasmsCD4+ T cellsPreventionWithaferin A

Identifiers

PMID42079342
PMCPMC13128505

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.