In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
14 authors.
Athina ZervaInstitute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.ORCID 0009-0005-5221-9471 Nicolai D RaigInstitute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.
Zaile ZhuangDepartment of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California 94305, United States.ORCID 0000-0002-3294-5805 Andreas KrämerInstitute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.ORCID 0000-0003-3294-2660 Johannes DopferInstitute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.ORCID 0009-0008-6356-1864 Riley TogashiDepartment of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California 94305, United States.
Martin P SchwalmInstitute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.ORCID 0000-0002-1252-1829 Lewis ElsonInstitute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.ORCID 0009-0004-6142-3653 Julia M FrischkornInstitute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.ORCID 0009-0006-7748-931X Benedict-Tilman BergerInstitute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.ORCID 0000-0002-3314-2617 Susanne MüllerInstitute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.
James K ChenDepartment of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California 94305, United States.ORCID 0000-0002-9220-8436 Stefan KnappInstitute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.ORCID 0000-0001-5995-6494 Thomas HankeInstitute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.ORCID 0000-0001-7202-9468 Funding
Chemical tools for developmental biologyR35GM127030 · NIGMS · STANFORD UNIVERSITY · PI JAMES K CHEN · 2018 to 2026
$6.3MMolecular Pharmacology Training ProgramT32GM136631 · NIGMS · STANFORD UNIVERSITY · PI BOGYO, MATTHEW, CHEN, JAMES K · 2021 to 2025
$2.0MNIGMS NIH HHS R35 GM127030NIGMS NIH HHS T32 GM136631
6 · The paper itselfAbstract
Homeodomain-interacting protein kinase 4 (HIPK4) remains an understudied member of the dark kinome. While genetic knockout studies suggest roles for HIPK4 in spermiogenesis and cutaneous squamous cell carcinoma, whether these cellular functions can be recapitulated by pharmacological inhibition remains to be determined. However, such investigations have been hampered by a lack of high-quality chemical tools. To address this, we employed a rational design strategy utilizing macrocyclization of a bosutinib-based scaffold. Systematic optimization led to the discovery of
Identifiers
PMID42079299
PMCPMC13131581
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