Evidence map›Paper›PMID 42079258›Full record

ArticlebioRxiv : the preprint server for biology2026

A double-blinded, placebo-controlled field trial of an OspA-based oral reservoir targeted vaccine against

Amy M Schwartz, Ferney Henao-Ceballos, Kathryn Arnold, Julia Poje, Max Waugh, Greg Joyner, Jose F Azevedo, Tyler Baccam, Eric Kontowicz, Kurayi Mahachi and 8 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Amy M SchwartzUniversity of Iowa, Iowa City, IA, USA.
Ferney Henao-CeballosUniversity of Iowa, Iowa City, IA, USA.
Kathryn ArnoldUniversity of Iowa, Iowa City, IA, USA.
Julia PojeUniversity of Iowa, Iowa City, IA, USA.
Max WaughUniversity of Iowa, Iowa City, IA, USA.
Greg JoynerUniversity of Tennessee Health Science Center, Memphis, TN, USA.ORCID 0000-0001-9333-6600
Jose F AzevedoUniversity of Tennessee Health Science Center, Memphis, TN, USA.
Tyler BaccamUniversity of Iowa, Iowa City, IA, USA.
Eric KontowiczUniversity of Iowa, Iowa City, IA, USA.
Kurayi MahachiUniversity of Iowa, Iowa City, IA, USA.
Paige WituckiUniversity of Iowa, Iowa City, IA, USA.
Suman KunduUniversity of Tennessee Health Science Center, Memphis, TN, USA.ORCID 0000-0002-8591-1166
Nisha NairUniversity of Tennessee Health Science Center, Memphis, TN, USA.
Felix Pabon-RodriguezIndiana University School of Medicine, Indianapolis, IN, USA.
Grant BrownUniversity of Iowa, Iowa City, IA, USA.
Maryland Field Team
Christine PetersenUniversity of Iowa, Iowa City, IA, USA.
Maria Gomes-SoleckiUniversity of Tennessee Health Science Center, Memphis, TN, USA.

Funding

Field trial and modeling of transmission blocking vaccine to prevent Lyme diseaseR01AI139267 · NIAID · UNIVERSITY OF IOWA · PI BROWN, GRANT D, GOMES-SOLECKI, MARIA · 2019 to 2023
$3.6M
Intranasal Vaccine Against Lyme DiseaseR44AI167605 · NIAID · IMMUNO TECHNOLOGIES, INC. · PI GOMES-SOLECKI, MARIA · 2022 to 2024
$3.0M
ImmunoPET Probes for the Imaging of Lyme DiseaseR01AI175417 · NIAID · HUNTER COLLEGE · PI Maria Gomes-Solecki, WEIGANG QIU · 2023 to 2026
$2.2M
NIAID NIH HHS R01 AI139267NIAID NIH HHS R01 AI175417NIAID NIH HHS R44 AI167605
6 · The paper itself

Abstract

Lyme disease, caused by

Indexed as

Borrelia burgdorferiField studyLyme diseaseNymphal infection prevalenceOspA-based vaccinePeromyscus leucopusReservoir targeted vaccineTransstadial transmission

Identifiers

PMID42079258
PMCPMC13131542

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.