ArticlebioRxiv : the preprint server for biology2026
Tandem bromodomains of BRD4 cooperatively read poly-acetylated nucleosomes to enhance chromatin engagement and regulate breast cancer phenotypes.
Nathaniel T Burkholder, Shwu-Yuan Wu, Jackson Handy, Cole Bertram, Matthew R Marunde, Irina K Popova, Krzysztof Krajewski, Cheng-Ming Chiang, Brian D Strahl
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
9 authors.
Nathaniel T BurkholderDepartment of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina, 27599, USA.ORCID 0000-0002-1769-3750 Shwu-Yuan WuSimmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Jackson HandyDepartment of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina, 27599, USA.
Cole BertramDepartment of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina, 27599, USA.
Irina K PopovaEpiCypher Inc., Durham, NC 27709, USA.
Krzysztof KrajewskiDepartment of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina, 27599, USA.
Cheng-Ming ChiangSimmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Brian D StrahlDepartment of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina, 27599, USA.ORCID 0000-0002-4947-6259 Funding
Mechanisms of chromatin and transcriptional regulationR35GM126900 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Brian D Strahl · 2018 to 2026
$5.5MOpposing Functions of BRD4 Isoforms in Breast CancerR01CA251698 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI CHIANG, CHENG-MING · 2020 to 2024
$2.3MMultiplex nucleosome-based profiling for the development of next-generation chromatin labeling reagentsR44GM136172 · NIGMS · EPICYPHER, INC. · PI SUN, ZU-WEN · 2020 to 2021
$1.8MHigh-throughput methyltransferase assays using recombinant nucleosome substratesR44GM117683 · NIGMS · EPICYPHER, INC. · PI SUN, ZU-WEN · 2018 to 2019
$1.7MBarcoded nucleosomes for analyzing combinatorial epigenetic regulatorsR44GM116584 · NIGMS · EPICYPHER, INC. · PI SUN, ZU-WEN · 2017 to 2018
$1.6MSmall Compound Inhibitors Targeting HPV Genome ReplicationR01CA288743 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI CHENG-MING CHIANG · 2025 to 2026
$1.3MNCI NIH HHS R01 CA251698NCI NIH HHS R01 CA288743NIGMS NIH HHS R35 GM126900NIGMS NIH HHS R44 GM116584NIGMS NIH HHS R44 GM117683NIGMS NIH HHS R44 GM136172
6 · The paper itselfAbstract
Bromodomain-containing protein 4 (BRD4) is an acetyl-lysine reader protein implicated in transcriptional control and oncogenesis, yet how its tandem bromodomains (BD1-2) contribute to nucleosomal engagement remains unresolved. Here we show that the tandem bromodomains of BRD4 cooperatively engage poly-acetylated histone H4 tails and nucleosomes
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PMID42079226
PMCPMC13131612
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