Evidence map›Paper›PMID 42079220›Full record

ArticlebioRxiv : the preprint server for biology2026

Expanding P-NET, a multi-purpose biologically informed deep learning framework.

Marc Glettig, Andrew Zhou, Chenzhang Zhou, Giuseppe Tarantino, Tyler Aprati, Eliezer M Van Allen, David Liu, Haitham Elmarakeby

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marc GlettigDana-Farber Cancer Institute, Boston, MA, USA.
Andrew ZhouDana-Farber Cancer Institute, Boston, MA, USA.
Chenzhang ZhouDana-Farber Cancer Institute, Boston, MA, USA.
Giuseppe TarantinoDana-Farber Cancer Institute, Boston, MA, USA.
Tyler ApratiDana-Farber Cancer Institute, Boston, MA, USA.
Eliezer M Van AllenDana-Farber Cancer Institute, Boston, MA, USA.
David LiuDana-Farber Cancer Institute, Boston, MA, USA.
Haitham ElmarakebyDana-Farber Cancer Institute, Boston, MA, USA.

Funding

Molecular and immune drivers of immunotherapy responsiveness in prostate cancerU01CA233100 · NCI · DANA-FARBER CANCER INST · PI FONG, LAWRENCE, VAN ALLEN, ELIEZER M · 2018 to 2022
$4.2M
Integrative Somatic and Germline Computational Biology to Redefine Clinical Actionability in Solid TumorsR01CA227388 · NCI · DANA-FARBER CANCER INST · PI VAN ALLEN, ELIEZER M · 2018 to 2022
$2.0M
Dissecting Therapeutic Resistance and Progression in Metastatic Melanoma Through Clinical Computational OncologyK08CA234458 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI LIU, DAVID · 2018 to 2022
$1.2M
NCI NIH HHS K08 CA234458NCI NIH HHS R01 CA227388NCI NIH HHS U01 CA233100
6 · The paper itself

Abstract

We present expanded P-NET, a versatile framework for deep learning in computational biology based on P-NET, leveraging biological pathways for interpretable predictions. Our framework achieves competitive performance in genomic & transcriptomic prediction tasks. We demonstrate its stability and interpretability compared to traditional machine learning models. P-NET 2.0 incorporates gene and pathway information, providing valuable insights into complex biological processes. The framework is publicly available, enabling its application to various computational biology tasks.

Identifiers

PMID42079220
PMCPMC13131806

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.