Evidence map›Paper›PMID 42079197›Full record

ArticlebioRxiv : the preprint server for biology2026

Rewiring Mitochondrial Phosphatidylethanolamine Metabolism Identifies New and Unaccounted Trafficking Steps.

Rashima Prem, Erica Avery, Juliana M Marquez, Chi Xie, Steven M Claypool

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PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Rashima PremDepartment of Physiology, Pharmacology and Therapeutics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Erica AveryDepartment of Physiology, Pharmacology and Therapeutics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Juliana M MarquezDepartment of Physiology, Pharmacology and Therapeutics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Chi XieDepartment of Physiology, Pharmacology and Therapeutics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Steven M ClaypoolDepartment of Physiology, Pharmacology and Therapeutics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0001-5316-1623

Funding

Mitochondrial phosphatidylethanolamine metabolismR01GM111548 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI CLAYPOOL, STEVEN MICHAEL · 2014 to 2021
$2.8M
Endoplasmic reticulum-assisted mitochondrial precursor biogenesis and quality controlR01GM151746 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Steven Michael Claypool · 2023 to 2026
$1.3M
NIGMS NIH HHS R01 GM111548NIGMS NIH HHS R01 GM151746
6 · The paper itself

Abstract

The distinct compositions of the two mitochondrial membranes are generated through a combination of phospholipids that mitochondria can make and those they take; both processes depend on a series of distinct lipid trafficking steps. Mitochondria make phosphatidylethanolamine (PE) through the action of the phosphatidylserine decarboxylase Psd1, an intermembrane space (IMS)-facing integral inner membrane (IM) protein. Psd1 has been proposed to act on its endoplasmic reticulum-derived substrate, phosphatidylserine (PS), after its transport to the mitochondrial outer membrane (OM) and either following its Ups2/Mdm35-mediated transport across the IMS to the IM or instead, on the IMS-side of the OM in a process enabled by the mitochondrial contact site and cristae organizing system (MICOS). Here, we implement a two-pronged Psd1 rewiring-based strategy predicted to either 1) circumvent the need for Ups2/Mdm35 and/or MICOS; or 2) selectively ablate the ability of Psd1 to work

Indexed as

lipid transportMembrane diversitymetabolic rewiringmitochondriaphospholipid metabolism

Identifiers

PMID42079197
PMCPMC13131618

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.