ArticlebioRxiv : the preprint server for biology2026
Simultaneous Inhibition of ACLY and OGDH Has a Synergistic Effect on Hepatocellular Carcinoma Cell Lines.
Mehdi Dehghan Manshadi, Nagesh Kishan Panchal, Lu-Zhe Sun, Payam Setoodeh, Habil Zare
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
5 authors.
Mehdi Dehghan ManshadiDepartment of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
Nagesh Kishan PanchalDepartment of Cell Systems & Anatomy, University of Texas Health San Antonio, San Antonio, Texas.
Lu-Zhe SunDepartment of Cell Systems & Anatomy, University of Texas Health San Antonio, San Antonio, Texas.
Payam SetoodehDepartment of Chemical Engineering, School of Chemical, Petroleum and Gas Engineering, Shiraz University, Shiraz, Iran.
Habil ZareGlenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Science Center, San Antonio, Texas, USA.
Funding
DISCOVERY - Statistics and Analysis CoreU19NS115388 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Steven M Greenberg, Natalia S Rost · 2019 to 2026
$75.4MSouth Texas Alzheimer's Disease Research CenterP30AG066546 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Sudha Seshadri · 2021 to 2026
$24.0MPRECURSORS OF STROKE INCIDENCE AND PROGNOSISR01NS017950 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Hugo Javier Aparicio, Jose Rafael Romero · 1985 to 2026
$22.9MPlasma Proteome and Risk of Alzheimer Dementia and Related Endophenotypes in the Framingham StudyRF1AG063507 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI GERSZTEN, ROBERT E, RAMACHANDRAN, VASAN S · 2019 to 2019
$4.2MMechanisms of tau- and aging-induced neurological dysfunction: Focus on the nucleusR01AG057896 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FROST, BESS · 2019 to 2023
$2.8MHigh Resolution Profiling of Senescent Neurons and Their Microenvironments in Postmortem Human Brain Tissue Spanning Eight Decades of LifeR01AG068293 · NIA · WASHINGTON UNIVERSITY · PI ORR, MIRANDA ETHEL · 2020 to 2025
$2.0MInvestigating the role of transposable element dysregulation as a driver of neurotoxicity in tauopathyRF1NS112391 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FROST, BESS · 2019 to 2019
$1.9MProteasome dysfunction as a driver of age-associated risk for Alzheimer's disease onset and progressionR01AG065301 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI PICKERING, ANDREW MICHAEL · 2024 to 2024
$487kThe pathogenic effects of senescent cells on their microenvironments and their role in human brain agingR21AG087907 · NIA · WASHINGTON UNIVERSITY · PI Miranda Ethel Orr · 2024 to 2026
$431kNIA NIH HHS P30 AG066546NIA NIH HHS R01 AG057896NIA NIH HHS R01 AG065301NIA NIH HHS R01 AG068293NIA NIH HHS R21 AG087907NIA NIH HHS RF1 AG063507NINDS NIH HHS R01 NS017950NINDS NIH HHS RF1 NS112391NINDS NIH HHS U19 NS115388
6 · The paper itselfAbstract
Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide. Current treatments offer limited efficacy and no definitive cure, underscoring the urgent need for more selective and effective therapeutic strategies. This study investigated the synthetic lethality caused by co-targeting two metabolic genes, ATP citrate lyase (
Indexed as
ACLYHCCHepatocellular CarcinomaOGDHSynergistic Effectsynthetic lethal
Identifiers
PMID42079189
PMCPMC13131670
What OpenQuestion holds
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