Evidence map›Paper›PMID 42079178›Full record

ArticlebioRxiv : the preprint server for biology2026

Shenwei Zhang, Colin Buttimer, Kai R Trepka, Kathy N Lam, Luis A Ramirez Hernandez, Paola Soto-Perez, Cecilia Noecker, Paolo Canigiula, Edwin F Ortega, Jenny Lee and 10 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Shenwei ZhangDepartment of Microbiology & Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0009-0007-9399-5690
Colin ButtimerAPC Microbiome Ireland and School of Microbiology, University College, Cork, T12 YT20, Ireland.
Kai R TrepkaDepartment of Microbiology & Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.
Kathy N LamDepartment of Microbiology & Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0003-1543-0161
Luis A Ramirez HernandezDepartment of Microbiology & Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.
Paola Soto-PerezDepartment of Microbiology & Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.
Cecilia NoeckerDepartment of Microbiology & Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.
Paolo CanigiulaDepartment of Microbiology & Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.
Edwin F OrtegaDepartment of Microbiology & Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.
Jenny LeeDepartment of Microbiology & Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.
Lorenzo RamirezDepartment of Microbiology & Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.
Gina PartipiloDepartment of Microbiology & Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.
Hugh B LawrenceDepartment of Microbiology & Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.
Francesca BottaciniDepartment of Biological Sciences, Munster Technological University, T12 P928 Cork, Ireland.
Lorraine A DraperAPC Microbiome Ireland and School of Microbiology, University College, Cork, T12 YT20, Ireland.
R Paul RossAPC Microbiome Ireland and School of Microbiology, University College, Cork, T12 YT20, Ireland.
Aidan CoffeyAPC Microbiome Ireland and School of Microbiology, University College, Cork, T12 YT20, Ireland.
Andrey ShkoporovAPC Microbiome Ireland and School of Microbiology, University College, Cork, T12 YT20, Ireland.ORCID 0000-0002-5547-8672
Colin HillAPC Microbiome Ireland and School of Microbiology, University College, Cork, T12 YT20, Ireland.
Peter J TurnbaughDepartment of Microbiology & Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0002-0888-2875

Funding

Predicting and preventing drug metabolism by the human gut microbiomeR01HL122593 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Peter James Turnbaugh · 2016 to 2026
$5.7M
Metabolism of cancer chemotherapeutics by the human gut microbiomeR01CA255116 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Peter James Turnbaugh · 2023 to 2026
$3.1M
Host-microbiome interactions shape the metabolic effects of ketogenic dietsR01DK114034 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI TURNBAUGH, PETER JAMES · 2020 to 2024
$2.5M
Establishing the feasibility of editing the human gut microbiomeR01AT011117 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI TURNBAUGH, PETER JAMES · 2020 to 2023
$1.6M
Systems-level analysis of the metabolism and ecology of genetically intractable gut bacteriaF32GM140808 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NOECKER, CECILIA · 2021 to 2022
$134k
NCCIH NIH HHS R01 AT011117NCI NIH HHS R01 CA255116NHLBI NIH HHS R01 HL122593NIDDK NIH HHS R01 DK114034NIGMS NIH HHS F32 GM140808
6 · The paper itself

Abstract

Bacteriophages are a promising tool for microbiome editing, yet their development has been constrained by limited insights into bacteriophage-host interactions within their shared mammalian body habitat. We isolated a lytic phage ΦKL11 that efficiently targets a disease-associated member of the human gut microbiota,

Indexed as

bacteriophagecapsular polysaccharidechromosomal inversionEggerthella lentagenomic structural variationhuman gut microbiomemicrobiome editingphage-host interactionphage resistancephase variation

Identifiers

PMID42079178
PMCPMC13131767

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.