ArticlebioRxiv : the preprint server for biology2026
Gene regulatory co-option drives birdsong neural circuit specialization.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
7 authors.
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Abstract
As animals evolve complex motor skills, they acquire more diverse supporting motor circuits in their nervous systems. Yet the molecular mechanisms driving motor circuit evolution remain poorly understood. Birdsong, a learned complex motor skill with parallels to human speech, is controlled by a dedicated neural circuit - the song system - that is distinguished from nearby sensorimotor regions by molecular, physiological, and connectivity specializations. By profiling gene expression and chromatin accessibility in the songbird brain, we found that each projection neuron type in the song system has a molecularly similar sister neuron type in adjacent non-song regions; these sister neurons lack specialized gene expression and are transcriptionally similar to neurons in the chicken brain. The gene regulatory networks (GRNs) controlled by transcription factors
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