Evidence map›Paper›PMID 42079126›Full record

ArticlebioRxiv : the preprint server for biology2026

Ribosome biogenesis bottlenecks reveal vulnerabilities in cancer.

Lifei Jiang, Qiwei Yu, Sofia A Quinodoz, Jordy F Botello, Sabreen Alam, Jing Xia, Jonida Trako, Troy J Comi, Aya A Abu-Alfa, Yong Wei and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lifei JiangDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.ORCID 0009-0007-7291-8311
Qiwei YuLewis-Sigler Institute for Integrative Genomics, Princeton, NJ 08544, USA.ORCID 0000-0003-0610-3484
Sofia A QuinodozDepartment of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA.ORCID 0000-0003-1862-5204
Jordy F BotelloDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.ORCID 0000-0002-0163-0595
Sabreen AlamDepartment of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA.ORCID 0009-0007-5710-7756
Jing XiaDepartment of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA.
Jonida TrakoDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.ORCID 0009-0004-1462-6490
Troy J ComiOmenn-Darling Bioengineering Institute, Princeton University, Princeton, NJ 08544, USA.ORCID 0000-0002-3215-4026
Aya A Abu-AlfaDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.ORCID 0009-0003-8569-2164
Yong WeiDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Andrej KošmrljDepartment of Mechanical and Aerospace Engineering, Princeton, NJ 08544, USA.ORCID 0000-0001-6137-9200
Yibin KangDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.ORCID 0000-0002-1626-6730
Clifford P BrangwynneDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell growth requires elevated protein synthesis, which depends on the production of ribosomes. Ribosome biogenesis is a complex, multi-step pathway in which newly transcribed precursor ribosomal RNA (rRNA) undergoes coordinated processing and assembly in the nucleolus to produce the small and large ribosomal subunits (SSU and LSU).

Identifiers

PMID42079126
PMCPMC13131773

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.