Evidence map›Paper›PMID 42079105›Full record

ArticlebioRxiv : the preprint server for biology2026

Tissue-Specific Prevalence and Clonal Architecture of

Xinfeng Wang, Saumya D Sisoudiya, Mahad Bihie, Yves Greatti, Julián Grandvallet Contreras, Tomi W Jun, Smruthy Sivakumar, Kuan-Lin Huang

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xinfeng WangDepartment of Genetics and Genomic Sciences, Department of Artificial Intelligence and Human Health, Center for Transformative Disease Modeling, Tisch Cancer Institute, Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Saumya D SisoudiyaFoundation Medicine, Inc., Boston, MA, USA.
Mahad BihieMcMaster University, Hamilton, Canada.
Yves GreattiJohns Hopkins University.
Julián Grandvallet ContrerasDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Tomi W JunDepartment of Genetics and Genomic Sciences, Department of Artificial Intelligence and Human Health, Center for Transformative Disease Modeling, Tisch Cancer Institute, Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Smruthy SivakumarFoundation Medicine, Inc., Boston, MA, USA.
Kuan-Lin HuangDepartment of Genetics and Genomic Sciences, Department of Artificial Intelligence and Human Health, Center for Transformative Disease Modeling, Tisch Cancer Institute, Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-5537-5817

Funding

Integrative Approaches for Identifying Causal Gene-Cell Type Pairs of Complex DiseaseR35GM138113 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Kuan-lin Huang · 2020 to 2026
$3.0M
Genomics-Empowered AI for Personalized Cancer Risk Assessment, Monitoring, and PreventionUG3AG105083 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Paul Stuart Appelbaum, Wendy K Chung · 2026 to 2026
$1.5M
HSRD VA IVI 22-115NIA NIH HHS UG3 AG105083NIGMS NIH HHS R35 GM138113
6 · The paper itself

Abstract

Germline pathogenic variants in BRCA1 and BRCA2 confer disproportionately elevated cancer risks in breast and ovarian tissues, yet the basis for this tissue specificity remains incompletely understood. Here, we integrate bulk-tumor aneuploidy analysis across 340,824 cancer cases from three independent cohorts (TCGA, ICGC PCAWG, and FoundationCore) with single-cell whole-genome sequencing from two independent studies to investigate whether tissue-specific patterns of chromosomal deletion contribute to this phenomenon. We find that breast and ovarian cancers are consistently enriched for deletions of chromosome arms 17q and 13q-harboring the

Identifiers

PMID42079105
PMCPMC13131466

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.