Evidence map›Paper›PMID 42079091›Full record

ArticlebioRxiv : the preprint server for biology2026

XL-MS and De Novo Protein Design Identified a Common Motif for TREM2 Binding.

Doniesha Perera, Emmanuel Ajiboye, Kalana Pitakatuwana, Sophia Wier, Vincent Duong, Haifan Wu

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Doniesha PereraDepartment of Chemistry and Biochemistry, Wichita State University, Wichita, Kansas 67260, United States.
Emmanuel AjiboyeDepartment of Chemistry and Biochemistry, Wichita State University, Wichita, Kansas 67260, United States.
Kalana PitakatuwanaDepartment of Chemistry and Biochemistry, Wichita State University, Wichita, Kansas 67260, United States.
Sophia WierDepartment of Chemistry and Biochemistry, Wichita State University, Wichita, Kansas 67260, United States.
Vincent DuongDepartment of Chemistry and Biochemistry, Wichita State University, Wichita, Kansas 67260, United States.
Haifan WuDepartment of Chemistry and Biochemistry, Wichita State University, Wichita, Kansas 67260, United States.ORCID 0000-0002-2050-9950

Funding

Supplement for Google cloud build-outR24GM137786 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI Alan Tackett · 2020 to 2026
$15.4M
Chemical Tools to Target TREM2 in Alzheimer's DiseaseR15AG080493 · NIA · WICHITA STATE UNIVERSITY · PI WU, HAIFAN · 2023 to 2023
$412k
NIA NIH HHS R15 AG080493NIGMS NIH HHS R24 GM137786
6 · The paper itself

Abstract

Apolipoprotein E (

Indexed as

Cross-linking mass spectrometryde novo protein designprotein-protein dockingTREM2/ApoE

Identifiers

PMID42079091
PMCPMC13131458

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.