ArticlebioRxiv : the preprint server for biology2026
Ribosomal RNA methylation by GidB modulates discrimination of mischarged tRNA.
Zhuo Bi, Yu-Xiang Chen, Iris D Young, Mohamad T Dandan, Hemant Joshi, Hong-Wei Su, Yuemeng Chen, Jia-Yao Hong, James S Fraser, Babak Javid
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
10 authors.
Zhuo BiCenter for Global Health and Infectious Disease, Tsinghua University School of Medicine, Beijing, China.
Yu-Xiang ChenDivision of Experimental Medicine, University of California, San Francisco, CA, USA.
Iris D YoungDepartment of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA.
Mohamad T DandanDepartment of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA.
Hemant JoshiDivision of Experimental Medicine, University of California, San Francisco, CA, USA.
Hong-Wei SuCenter for Global Health and Infectious Disease, Tsinghua University School of Medicine, Beijing, China.
Yuemeng ChenCenter for Global Health and Infectious Disease, Tsinghua University School of Medicine, Beijing, China.
Jia-Yao HongCenter for Global Health and Infectious Disease, Tsinghua University School of Medicine, Beijing, China.
James S FraserDepartment of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-5080-2859 Babak JavidCenter for Global Health and Infectious Disease, Tsinghua University School of Medicine, Beijing, China.ORCID 0000-0002-6354-6305 Funding
Equipment for Discovering and Manipulating Macromolecular Conformational EnsemblesR35GM145238 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI James Solomon Fraser · 2022 to 2026
$3.1MAcquisition of an electron microscope for high-resolution single particle cryo-EMS10OD021741 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHENG, YIFAN · 2016 to 2016
$2.0MGlacios™ Cryo Transmission Electron Microscope with 200 kV XFEG opticsS10OD026881 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHENG, YIFAN · 2019 to 2019
$1.8MRegulation of mycobacterial adaptive mistranslationR56AI185094 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JAVID, BABAK · 2024 to 2024
$680kLinux cluster for near atomic resolution single particle cryo-EMS10OD020054 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHENG, YIFAN · 2015 to 2015
$456kNIAID NIH HHS R56 AI185094NIGMS NIH HHS R35 GM145238NIH HHS S10 OD020054NIH HHS S10 OD021741NIH HHS S10 OD026881Wellcome Trust
6 · The paper itselfAbstract
Despite redundant cellular pathways to minimize translational errors, errors in protein synthesis are common. Pathways and mechanisms to minimize errors are classified as pre-ribosomal or ribosomal. Pre-ribosomal pathways are primarily concerned with the appropriate charging of tRNAs with their cognate amino acid. By contrast, the ribosomal decoding centre is considered 'blind' to mischarged tRNAs since these have cognate codon•anti-codon pairing. Here, we identified that in mycobacteria, deletion of the 16S ribosomal RNA methyltransferase
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PMID42079085
PMCPMC13131534
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