ArticlebioRxiv : the preprint server for biology2026
Proteome-Driven Phenotyping of Identified Single Neurons in Intact Brain Tissue by Aspiration Patch Proteomics.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Single-cell proteomics has advanced rapidly, but direct proteome measurements from identified neurons in intact brain tissue remain difficult because most workflows require cell isolation and recent patch-based studies have emphasized whole-soma retrieval. Here we show that aspiration-based patch proteomics enables deep proteome profiling of identified single neurons directly in acute mouse brain slices. We combined fluorescence-guided patch-clamp microsampling, minimal-loss bottom-up proteomics, and high-sensitivity capillary electrophoresis-timsTOF mass spectrometry to analyze partial somal aspirates from dopaminergic, parvalbumin, and serotonergic neurons
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