Evidence map›Paper›PMID 42079074›Full record

ArticlebioRxiv : the preprint server for biology2026

Unique nasal cell states induced by common pediatric respiratory viruses.

Jaclyn M L Walsh, Lillian J Juttukonda, Ying Tang, Ankita Chatterjee, Marc Elosua-Bayes, Erica Langan, Amanda Frischmann, Faith Taliaferro, Hannah R Matthews, Kyle Kimler and 25 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors.

Jaclyn M L WalshDivision of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0001-6292-1006
Lillian J JuttukondaDivision of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0002-4985-8505
Ying TangDivision of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0003-4357-2343
Ankita ChatterjeeJohn.C. Martin Center for Liver Research & Innovations, Kolkata, India.
Marc Elosua-BayesDivision of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, MA, USA.
Erica LanganDivision of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, MA, USA.
Amanda FrischmannDivision of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, MA, USA.
Faith TaliaferroDivision of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, MA, USA.
Hannah R MatthewsDivision of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, MA, USA.
Kyle KimlerDivision of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, MA, USA.
Chris M LentDivision of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, MA, USA.
Deb Purna KeyaChild Health Research Foundation, Dhaka, Bangladesh.
Preonath Chondrow DevChild Health Research Foundation, Dhaka, Bangladesh.
Apurba Rajib MalakerChild Health Research Foundation, Dhaka, Bangladesh.
Lubana TanviaChild Health Research Foundation, Dhaka, Bangladesh.
Arif Mohammad TanmoyChild Health Research Foundation, Dhaka, Bangladesh.ORCID 0000-0002-7769-8035
Supratim GhoshBRIC-National Institute of Biomedical Genomics, Kalyani, India.
Arindam MaitraBRIC-National Institute of Biomedical Genomics, Kalyani, India.
Apurba GhoshInstitute of Child Health, Kolkata, India.
Surupa BasuInstitute of Child Health, Kolkata, India.
Abigail S KaneDepartment of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.
Charles A CoomerDivision of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, MA, USA.
Alex K ShalekProgram in Immunology, Harvard Medical School, Boston, MA, USA.
Thushan I de SilvaDepartment of Infection, Immunity and Cardiovascular Disease, Medical School, University of Sheffield, Sheffield, UK.ORCID 0000-0002-6498-9212
Abdul Karim SesayMRC Unit the Gambia at London School of Hygiene & Tropical Medicine, Serrekunda, The Gambia.
Jessica EdwardsDepartment of Pathology/Microbiology, Princess Margaret Hospital, Nassau, Bahamas.
Corrine Sin QueeDivision of Haematology and Oncology, Department of Pediatrics, Princess Margaret Hospital, University of the West Indies, Nassau, Bahamas.
Wanda I GonzalezDepartment of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.
Lael M YonkerDepartment of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.
Sarah C GloverDepartment of Medicine, Section of Gastroenterology and Hepatology, Tulane University, New Orleans, LA, USA.
Partha MajumderBRIC-National Institute of Biomedical Genomics, Kalyani, India.ORCID 0000-0001-7009-7360
Yogesh HoodaChild Health Research Foundation, Dhaka, Bangladesh.ORCID 0000-0002-7181-9254
Senjuti SahaChild Health Research Foundation, Dhaka, Bangladesh.ORCID 0000-0001-6087-6766
Jose Ordovas-MontanesDivision of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0001-5444-5601
Bruce H HorwitzDivision of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0002-8123-8728

Funding

STRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI JONATHAN C KAGAN · 1986 to 2026
$32.4M
Neonatal Research Training ProgramT32HD098061 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Stella Kourembanas, Martha C. Sola-Visner · 2019 to 2026
$4.0M
Initiation of immune responses to SARS COV2 in the oral cavity and upper airwayR01DE031928 · NIDCR · UNIVERSITY OF MISSISSIPPI MED CTR · PI GILL DIAMOND, SARAH C GLOVER · 2022 to 2026
$3.8M
Balancing epithelial cell resistance and resilience to respiratory viral infectionsR01HL162642 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI Jose Manuel Ordovas-Montanes · 2023 to 2026
$3.4M
NRSA Training CoreTL1TR002543 · NCATS · HARVARD MEDICAL SCHOOL · PI MICHEL, THOMAS · 2018 to 2022
$3.4M
NCATS NIH HHS TL1 TR002543NHLBI NIH HHS R01 HL162642NICHD NIH HHS T32 HD098061NIDCR NIH HHS R01 DE031928NIDDK NIH HHS P30 DK034854
6 · The paper itself

Abstract

Respiratory viral infections in early childhood are major drivers of acute morbidity and long-term airway disease, yet how distinct viruses remodel the pediatric nasal mucosa at cellular resolution remains unresolved. Here, we generated a single-cell RNA sequencing atlas of 335,174 nasal epithelial and immune cells from 132 children under five years of age with SARS-CoV-2, rhinovirus, or respiratory syncytial virus (RSV) infection, alongside uninfected controls. Mapping viral transcripts to individual cells revealed virus-specific infected epithelial states: an NF-kB-responsive ciliated subset in SARS-CoV-2 and a previously undescribed

Identifiers

PMID42079074
PMCPMC13131565

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.