Evidence map›Paper›PMID 42079055›Full record

ArticlebioRxiv : the preprint server for biology2026

The inner nuclear membrane protein SUN1 regulates cullin-3 neddylation to maintain insulin signaling.

Kapil K Upadhyay, Yunshu Yang, Aren Shah, Venkatesha Basrur, Alexey I Nesvizhskii, Graham F Brady

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kapil K UpadhyayDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-0000-5085
Yunshu YangDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Aren ShahDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Venkatesha BasrurDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA.
Alexey I NesvizhskiiDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA.
Graham F BradyDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-8376-5871

Funding

Nuclear lamins and the hepatocyte nuclear envelope in nonalcoholic fatty liver diseaseK08DK120948 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BRADY, GRAHAM F. · 2020 to 2024
$839k
Role of SUN1 in MASLD and metabolic diseaseR03DK137052 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BRADY, GRAHAM F. · 2024 to 2025
$234k
NIDDK NIH HHS K08 DK120948NIDDK NIH HHS R03 DK137052
6 · The paper itself

Abstract

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease and strongly linked to obesity and insulin resistance. We previously reported that the common nuclear envelope variant rs6461378 (g.842031C>T;

Indexed as

cullin RING ligasesinsulin signalingneddylationnuclear envelope

Identifiers

PMID42079055
PMCPMC13131608

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.