ArticleIranian journal of basic medical sciences2026
Can monomethyl fumarate and nifedipine reduce ischemia reperfusion injury in rat ovary, and what is the share of oxidative stress-sensitive transcription factors HIF-1α, NF-κB, and Nrf2?
Article in Iranian journal of basic medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: This study aimed to investigate the potential protective roles of monomethyl fumarate (MMF) and nifedipine (NF) against ovarian ischemia-reperfusion (I/R) injury in rats, with a particular focus on the contribution of oxidative stress-sensitive transcription factors HIF-1α, NF-κB, and Nrf2. Materials and Methods: A rat model of ovarian I/R injury was established using 3-hr ischemia followed by 24-hour reperfusion. Ovarian hormone secretion capacity, oxidative stress-related biomolecular alterations, and apoptosis activation were analyzed using ELISA. Histopathological damage and apoptotic cell status were evaluated by hematoxylin-eosin (H&E) and immunohistochemical (IHC) staining. Expression levels of HIF-1α, NF-κB, Nrf2, and related downstream genes were determined using RT-qPCR. Results: I/R significantly altered the expression of oxidative stress-associated transcription factors and their downstream targets compared with ischemia alone ( Conclusion: MMF and NF exerted protective effects against ovarian I/R injury by modulating oxidative stress and apoptosis. These findings suggest that the coordinated regulation of HIF-1α, NF-κB, and Nrf2 pathways may play a pivotal role in reducing reperfusion-related ovarian tissue damage.
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