Evidence map›Paper›PMID 42078909›Full record

ArticleResearch square2026

Cysteines are critical determinants of spontaneous and seeded tau aggregation in cells.

Parvathy Jayan, Simran Rastogi, Vaibhav Bommareddy, Chad M Dashnaw, Jaime Vaquer-Alicea, Binh An Nguyen, Lorena Saelices, Sarah Shahmoradian, Charles L White, Marc I Diamond and 1 more

Abstract readPreprint
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Parvathy JayanCenter for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Simran RastogiCenter for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Vaibhav BommareddyCenter for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID https://orcid.org/0000-0001-7618-1491
Chad M DashnawCenter for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Jaime Vaquer-AliceaCenter for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Binh An NguyenCenter for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Lorena SaelicesCenter for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-1904-2150
Sarah ShahmoradianCenter for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID https://orcid.org/0000-0001-9752-7287
Charles L WhiteDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.ORCID 0000-0002-3870-2804
Marc I DiamondCenter for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-8085-7770
Lukasz A JoachimiakCenter for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0003-3061-5850

Funding

Seeds and Strains Derived from Tau Monomer - Perez Diversity SupplementRF1AG065407 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI DIAMOND, MARC I, JOACHIMIAK, LUKASZ A. · 2020 to 2021
$3.2M
Structural profiling of tauopathy seedsRF1AG076459 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI JOACHIMIAK, LUKASZ A. · 2023 to 2023
$1.2M
TEM for UT Southwestern Electron Microscopy Core FacilityS10OD021685 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI LUBY-PHELPS, KATHERINE J · 2017 to 2017
$398k
SEM for UT Southwestern EM Core FacilityS10OD020103 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI LUBY-PHELPS, KATHERINE J · 2015 to 2015
$306k
NIA NIH HHS RF1 AG065407NIA NIH HHS RF1 AG076459NIH HHS S10 OD020103NIH HHS S10 OD021685
6 · The paper itself

Abstract

The frontotemporal dementia-linked S320F mutation in the microtubule-associated protein tau promotes spontaneous aggregation, yet the structural basis of its amyloidogenesis remains unclear. Using cryo-electron microscopy, we determined the structure of an S320F

Identifiers

PMID42078909
PMCPMC13131862

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.