ArticleFrontiers in veterinary science2026
A novel method for establishing a rat model of knee osteoarthritis: knee joint fixation using medical polyurethane composite wraps.
Article in Frontiers in veterinary science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Knee osteoarthritis (KOA) is a leading cause of chronic pain and disability in humans, companion and farm animals, with socioeconomic burden and animal welfare concerns. KOA models are essential for advancing diagnostics, therapies, and preventive strategies. This study aimed to establish a reliable non-invasive rat KOA model and evaluate its translational value for comparative and clinical medicine. Methods: Twenty male Sprague-Dawley rats were randomly allocated to two groups: a model group ( Results: The examination of the knee joint cartilage in the model group revealed significant surface irregularities and roughness. Compared to the control group, the model group exhibited a notably higher Modified Lequesne MG score ( Conclusion: We developed a non-invasive rat KOA model using polyurethane bandage immobilization that recapitulates cross-species progressive OA pathology. This robust, low-cost platform enables early biomarker screening, disease-modifying therapy evaluation, and preventive intervention validation for veterinary/human OA, highlighting its translational value for comparative and clinical medicine.
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