ArticleInternational journal of general medicine2026
Association of Serum Albumin and the ApoB/ApoA1 Ratio with Acute Post-Stroke Cognitive Impairment: A Propensity Score-Matched Case-Control Study.
Article in International journal of general medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and Purpose: Evidence regarding the associations of serum albumin and apolipoprotein-related markers with acute cognitive impairment (CI) after stroke remains limited. This study investigated the associations of serum albumin and the apolipoprotein B/apolipoprotein A1 ratio (ApoB/ApoA1) with acute CI assessed within 7 days after first-ever ischemic stroke (IS). Methods: This retrospective single-center case-control study included patients with first-ever IS who completed the Chinese version of the Mini-Mental State Examination (MMSE) within 7 days after stroke onset. Patients with an MMSE score of ≤25 were classified into the CI group, and those with an MMSE score of >25 into the non-CI group. Propensity score matching was performed in a 1:1 ratio (caliper = 0.07; without replacement) based on age, sex, and education level. Associations were evaluated using logistic regression analyses. Results: Among 371 eligible patients, 175 were in the CI group and 196 were in the non-CI group. After matching, 144 pairs were included. In the matched cohort, albumin, ApoB, and ApoB/ApoA1 were lower in the CI group. In multivariable analysis, higher albumin (adjusted odds ratio 0.934, 95% confidence interval 0.887-0.983; P=0.009) and higher ApoB/ApoA1 (adjusted odds ratio 0.429, 95% confidence interval 0.200-0.919; P=0.030) were independently associated with lower odds of acute CI after stroke. The lowest odds of acute CI were observed at albumin levels of 39.300-41.400 g/L and an ApoB/ApoA1 ratio of ≥0.883. Conclusion: In patients with first-ever IS, higher serum albumin levels and a higher ApoB/ApoA1 ratio were associated with lower odds of acute CI within 7 days after stroke. Multicenter prospective studies are needed to validate these findings and clarify the underlying mechanisms.
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