Evidence map›Paper›PMID 42078818›Full record

ArticleIEEE transactions on radiation and plasma medical sciences2026

CHEMONO: a Cherenkov-Only Monolithic Detector for PGI in Proton Range Verification.

Leonor Rebolo, Ryan Heller, Marta Freire, Pedro Correia, Ana Luisa Silva, Sara St James, Antonio J González, Joshua W Cates, Gerard Ariño-Estrada

Abstract read
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In one paragraph

Article in IEEE transactions on radiation and plasma medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Current Status of Cherenkov-Based Gamma Detectors for TOF-PET and Proton Range Verification.IEEE transactions on radiation and plasma medical sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Leonor ReboloDepartment of Biomedical Engineering of the University of California, Davis (UCD), Davis, California, USA.
Ryan HellerLawrence Berkeley National Laboratory, Berkeley, CA, USA.
Marta FreireInstituto de Instrumentación para Imagen Molecular (I3M), Valencia, Spain.
Pedro Correiai3N - Institute for Nanostructures, Nanomodelling and Nanofabrication, Department of Physics of the University of Aveiro, Portugal.
Ana Luisa Silvai3N - Institute for Nanostructures, Nanomodelling and Nanofabrication, Department of Physics of the University of Aveiro, Portugal.
Sara St JamesHuntsman Cancer Institute at the University of Utah, Salt Lake City, UT, USA.
Antonio J GonzálezInstituto de Instrumentación para Imagen Molecular (I3M), Valencia, Spain.
Joshua W CatesLawrence Berkeley National Laboratory, Berkeley, CA, USA.
Gerard Ariño-EstradaDepartment of Biomedical Engineering of the University of California, Davis (UCD), Davis, California, USA.

Funding

Real-time in vivo proton range verification in proton therapy with thallium bromide detectorsR01EB029533 · NIBIB · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ARIÑO ESTRADA, GERARD · 2021 to 2024
$2.6M
NIBIB NIH HHS R01 EB029533
6 · The paper itself

Abstract

Proton range verification (PRV) in proton therapy is an unmet clinical need. Prompt-gamma imaging (PGI) using thick collimators is a PRV modality that has obtained the most success to-date. The gamma detectors in such approach consist of scintillation crystals coupled to photodetectors. In this work, we report the development and use of detectors made of monolithic pure Cherenkov emitter crystals for the same purpose. We demonstrate for the first time the ability of such detector configuration to provide spatial resolution information in one direction using measurements from a collimated slit. The detector consisted of a PbF2 crystal with dimensions 25 × 25 × 10 mm

Indexed as

Monolithic CrystalsPrompt-Gamma imagingProton range verificationPure-Cherenkov Emitters

Identifiers

PMID42078818
PMCPMC13132495

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.