ArticleFrontiers in oncology2026
MRI-derived tumor volume vs. pathological tumor diameter: a comparative study of prognostic value for disease-free survival in multifocal/multicentric breast cancer.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and objective: Multifocal/multicentric breast cancer (MMBC) is characterized by multiple tumor foci in the same breast, but conventional T staging based on the largest lesion (Dmax) may underestimate true tumor burden. This study aimed to evaluate whether MRI-derived tumor volumes (Vmax and Vsum) provide superior prognostic value for disease-free survival (DFS) compared with pathological tumor diameters (Dmax and Dsum). Materials and methods: We retrospectively reviewed 111 patients with MMBC treated between January 2015 and June 2020. Tumor volumes were quantified from preoperative 3T MRI, and pathological diameters and clinicopathological variables were collected from medical records. To normalize distributions, tumor size metrics were log Results: Log Conclusions: MRI-derived sum of tumor volumes (Vsum) provides superior prognostic value for DFS in MMBC compared with diameter-based metrics. Integrating Vsum with lymph node burden may improve risk stratification and support personalized treatment planning.
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