ArticleFrontiers in oncology2026
Cold-spot driven local failure after stereotactic body radiation therapy for colorectal liver metastases.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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17 authors.
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Abstract
Background: This single-institution retrospective study investigated whether actual dosimetric plan quality metrics better predict freedom from local progression (FFLP) than nominal prescription dose after stereotactic body radiation therapy (SBRT) for colorectal liver metastases (CLM). Methods: A total of 116 patients with 128 CLM treated with SBRT (≥70 Gy biologically effective dose [BED Results: With a median follow-up of 22.3 months, 1-year and 2-year FFLP rates were 74.5% and 58.8%, respectively. On univariable analyses, extent of metastasis, number of systemic therapy lines, pre- and post-SBRT carcinoembryonic antigen, PTV, prescription dose, and other plan parameters (Dmax, Dmin, Dmean, D2%, D95%, D98%, D99%) were significant. In the final multivariable model, PTV Dmin (HR 0.89 per 10 Gy BED Conclusion: PTV Dmin emerged as the most robust dosimetric predictor of FFLP. Incorporating PTV Dmin into SBRT planning may improve FFLP beyond nominal prescription dose.
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