ArticleAnnals of medicine and surgery (2012)2026
Da-yuan-yin decoction ameliorates inflammatory injury in severe pancreatitis by protecting intestinal mucosal barrier and immune function and preventing intestinal dysbiosis.
Article in Annals of medicine and surgery (2012), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Acute pancreatitis (AP) is a common gastrointestinal condition characterized by inflammation of the pancreas. AP treatment is highly challenging due to the long hospital stays, higher medical expenses, and multiple complications. Traditional Chinese medicine has been used in China for thousands of years and is clinically proven to be a safe and effective treatment strategy for pancreatitis. Methods: To investigate whether a da-yuan-yin (DYY) decoction ameliorates inflammatory injury in severe pancreatitis. The severe acute pancreatitis (SAP) model was established by retrograde injection of 5% sodium taurocholate into the bile duct of male Sprague-Dawley rats. We detected the intestinal mucosal barrier function and intestinal immune function, and analyzed the changes of gut flora using the 16S rRNA gene testing. Results: Cell damage was more serious in SAP than that of DYY + SAP. The expression of myeloperoxidase and EGF-like module-containing mucin-like hormone receptor-like 1 in SAP was significantly higher than in DYY + SAP. Serum endotoxin, d-lactate, intestinal fatty acid-binding protein, interleukin (IL)-1β, and IL-10 of SAP and DYY + SAP were significantly increased. Plasma vasoactive intestinal peptide (VIP) was significantly reduced in both SAP and DYY + SAP; plasma VIP in DYY + SAP was significantly lower than in SAP. Levels of CD3 Conclusion: The DYY decoction may reduce tissue injury, protect the intestinal mucosal barrier, enhance intestinal immune function, and help prevent intestinal dysbiosis in ascitic fluid and stool specimens.
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