ArticleAnnals of medicine and surgery (2012)2026
COVID-19 vaccine-associated liver injury and autoimmune hepatitis: a case series.
Article in Annals of medicine and surgery (2012), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Coronavirus disease 2019 (COVID-19) vaccines have significantly reduced global morbidity and mortality. While generally safe, rare immune-mediated liver injuries, including autoimmune hepatitis (AIH) and drug-induced liver injury have been reported post-vaccination. Case series: We present three cases that developed liver injury following Pfizer-BioNTech (BNT162b2) COVID-19 vaccination. Case 1 describes a 64-year-old female with new-onset AIH confirmed by serology, histology, and clinical response to corticosteroids. Case 2 is a 36-year-old female who developed transient liver injury that resolved without immunosuppressive therapy. Case 3 involves a 35-year-old male with a history of AIH in remission who experienced a flare, requiring intensification of immunosuppressive treatment. Discussion: The mechanisms underlying liver injuries following COVID-19 vaccination remain incompletely understood, and a causal relationship has not been definitively established. One possible mechanism is molecular mimicry, in which the immune system targets liver cells after recognizing similarities with viral spike proteins. Vaccine adjuvants may also contribute to immune dysregulation in individuals with certain genetic factors like HLA-DR3 and HLA-DR4, which have been linked to AIH. Multiple reviews of vaccine-associated liver injury suggest that the majority of patients improve with immunosuppressive therapy, although there have been rare reports of severe presentations, including progression to liver failure. Conclusion: Although rare, COVID-19 vaccines may be associated with various forms of liver injury. This case series highlights the heterogeneous clinical spectrum and disease course of COVID-19 vaccine-associated liver injuries, ranging from transient liver enzyme abnormalities to more persistent disease ,such as autoimmune hepatitis, requiring treatment. While causality can not be established, these findings emphasize the importance of clinical vigilance and individualized assessment in at-risk populations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.