Evidence map›Paper›PMID 42078568›Full record

ArticleNAR genomics and bioinformatics2026

RNAStructuromeDB: a transcriptome-wide database of predicted RNA secondary structures with integrated APIs for functional annotation and RNA-targeted drug discovery.

Abdelraouf O Dapour, Jacopo Manigrasso, Warren B Rouse, Giuseppina La Sala, Miles V Aronnax, Leonardo De Maria, Russell S Hamilton, Sergio Martinez Cuesta, Anders Hogner, Walter N Moss

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NAR genomics and bioinformatics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Abdelraouf O DapourBioinformatics and Computational Biology Program, Iowa State University, Ames, IA 50011, United States.
Jacopo ManigrassoMedicinal Chemistry, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Mölndal 431 50, Sweden.
Warren B RouseRoy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, United States.ORCID https://orcid.org/0000-0002-5158-7572
Giuseppina La SalaMedicinal Chemistry, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Mölndal 431 50, Sweden.
Miles V AronnaxResearch IT, Iowa State University, Ames, IA 50011, United States.
Leonardo De MariaMedicinal Chemistry, Research and Development, Respiratory & Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Mölndal 431 50, Sweden.
Russell S HamiltonTranslational Science Experimental Medicine, Research and Development, Respiratory & Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Cambridge 431 50, United Kingdom.
Sergio Martinez CuestaData Sciences and Quantitative Biology, Discovery Sciences, R&D BioPharmaceuticals, AstraZeneca, Cambridge CB2 0AA, United Kingdom.
Anders HognerMedicinal Chemistry, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Mölndal 431 50, Sweden.
Walter N MossRoy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, United States.ORCID https://orcid.org/0000-0001-6419-5570

Funding

Finding, folding and characterizing the functions of disease-relevant RNA structuresR01GM133810 · NIGMS · IOWA STATE UNIVERSITY · PI Walter Moss · 2019 to 2026
$2.8M
NIGMS NIH HHS R01 GM133810
6 · The paper itself

Abstract

RNA structure critically governs biological function in both physiological and pathological contexts, making high-resolution structural maps essential for RNA-targeted therapeutics. Yet, despite recent advances, well-validated structural targets for drug design remain limited. To help bridge this gap, we generated the first genome-scale map of the human RNA structurome by applying ScanFold to >230 000 annotated human pre-mRNA transcripts, identifying sequences likely evolved to form highly stable and functional secondary structures. We also performed a global analysis of regions with

Indexed as

Databases, Nucleic AcidDrug DiscoveryNucleic Acid ConformationRNATranscriptomeBiocurationHumansMolecular Sequence AnnotationRNA PrecursorsSurvival of Motor Neuron 2 ProteinRNARNA PrecursorsSMN2 protein, humanSurvival of Motor Neuron 2 Protein

Identifiers

PMID42078568
PMCPMC13129543

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.