ArticleFrontiers in microbiology2026
Molecular epidemiology of antimicrobial resistance and virulence of carbapenem-resistant
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Carbapenem-resistant Methods: 108 CRKP isolates were collected from multiple hospitals in South China. The characteristics of the CRKP strains, including antimicrobial resistance genes, mutations and virulence factors, were analyzed using whole-genome sequencing and the software Kleborate. A phylogenetic tree was constructed to illustrate evolutionary diversification. Results: The main Sequence Type (ST) type, capsular serotype, and LPS serotype among CRKP isolates in South China were ST11, KL47, and OL101, respectively. KPC-2 was the most prevalent carbapenemase type. Notably, KPC-12, a recently identified and rarely reported variant of KPC-2, was discovered in four CRKP strains. All ST11 CRKP isolates harbored porin and efflux pump regulator mutations of AcrR-43%, OmpK35-17%, and OmpK36GD as well as fluoroquinolone mutations of GyrA-83I, GyrA-87G, and ParC-80I. All CRKP strains exhibited complex multi-drug resistance (MDR) phenotypes. The most common types of aerobactin ( Conclusion: In South China, highly virulent and MDR CRKP strains show a trend toward epidemic, underscoring the urgent need for ongoing genomic surveillance and stringent infection control measures. KPC-2 variant KPC-12 and ST413-1LV-KL112 hvCRKP, a novel type of hvCRKP carrying
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