Evidence map›Paper›PMID 42078538›Full record

ArticleFrontiers in microbiology2026

Molecular epidemiology and genetic characteristics of influenza viruses in a local pediatric population of eastern China, 2024.

Xiaoqing Sun, Xiang Li, Haiyan Chen, Tianyuan Lu, Zhaoqi Fang, Danyang Chen, Qiliang Cai, Jun Shen, Youhua Xie

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Xiaoqing Sun *Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Xiang Li *Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Haiyan Chen *Pediatric Department, Children's Hospital of Fudan University at Qidong, Nantong, China.
Tianyuan LuPediatric Department, Children's Hospital of Fudan University at Qidong, Nantong, China.
Zhaoqi FangKey Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Danyang ChenKey Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Qiliang CaiKey Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Jun ShenPediatric Department, Children's Hospital of Fudan University at Qidong, Nantong, China.
Youhua XieKey Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The persistent circulation of influenza viruses following the COVID-19 pandemic remains a major public health concern, yet local genomic epidemiology in pediatric populations is not well-defined. Methods: In 2024, we collected 490 influenza antigen-positive specimens from a pediatric hospital in Qidong, eastern China, and performed influenza genome enrichment-based whole-genome sequencing, yielding 425 genomes (86.73%) with at least hemagglutinin (HA) and neuraminidase (NA) segments. Results: A/H1N1 (45.41%), A/H3N2 (18.35%), and B/Victoria (36.24%) co-circulated, with two activity peaks in January and December. Phylogenetic analysis assigned these viruses to clades 6B.1A.5a.2a (A/H1N1), 3C.2a1b.2a.2a.3a.1 (A/H3N2), and V1A.3a.2 (B/Victoria). Positively selected sites in HA included lineage-specific residues such as position 210 in B/Victoria and positions 187 and 372 in A/H3N2. The oseltamivir resistance marker NA-H275Y was detected in 7/193 (3.65%) A/H1N1 strains, whereas no detected resistance to RNA polymerase inhibitors. Discussion: These findings highlight the co-circulation patterns, genetic diversity, and antiviral susceptibility profile of influenza viruses in a pediatric population in eastern China, supporting the importance of sustained genomic surveillance to guide local prevention strategies and clinical management.

Indexed as

East Chinainfluenza virusmolecular epidemiologypediatric populationwhole-genome sequencing

Identifiers

PMID42078538
PMCPMC13128664

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