ArticleOpen life sciences2026
Functionalized chitosan-graphene magnetic nanocomposites enhance collagen synthesis in scleral fibroblasts.
Article in Open life sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
To investigate the effects of magnetic stimulation mediated by magnetic/graphene (MNP/G) composite nanomaterials on human scleral fibroblast (HFSF) proliferation and collagen synthesis, exploring its potential for myopia prevention. MNP/G nanomaterials were synthesized via covalent co-precipitation and introduced into HFSF cultures. Cells were co-cultured with 30 μg/mL MNP/G and exposed to static magnetic stimulation (20 mT intensity). Proliferation was assessed via CCK-8 assay, morphology was observed using inverted phase-contrast microscopy, and hydroxyproline content was measured to quantify collagen synthesis. Magnetic stimulation significantly enhanced HFSF proliferation compared to non-stimulated controls, with no observed cytotoxicity. Microscopic analysis revealed improved cell density and spindle-like morphology in stimulated groups. Hydroxyproline assays demonstrated a marked increase in collagen synthesis following magnetic stimulation, suggesting enhanced extracellular matrix production. Notably, the combined application of MNP/G nanomaterials and magnetic stimulation yielded the highest collagen content among all experimental conditions. Magnetic stimulation using MNP/G nanomaterials promotes HFSF proliferation and collagen production, potentially strengthening scleral biomechanical properties. This approach may counteract scleral remodeling in myopia progression, offering a novel strategy for non-invasive myopia intervention.
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