Evidence map›Paper›PMID 42078373›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Antenatal Screening for Sexually Transmitted Infections to Reduce Preterm Birth or Low Birthweight (Philani Ndiphile Study): A Randomized Three-Group Trial.

Andrew Medina-Marino, Chibuzor M Babalola, Mandisa M Mdingi, Melissa L Wilson, Freedom Mukomana, Christina A Muzny, Christopher M Taylor, Ranjana Ms Gigi, Hyunsul Jung, Nicola Low and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Andrew Medina-MarinoDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Chibuzor M BabalolaDepartment of Population and Public Health Sciences, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.ORCID 0000-0003-3762-1620
Mandisa M MdingiResearch Unit, Foundation for Professional Development, East London, South Africa.ORCID 0000-0002-2795-0343
Melissa L WilsonDepartment of Population and Public Health Sciences, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.
Freedom MukomanaResearch Unit, Foundation for Professional Development, East London, South Africa.
Christina A MuznyDivision of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0002-4005-3858
Christopher M TaylorDepartment of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences, New Orleans, LA, USA.
Ranjana Ms GigiResearch Unit, Foundation for Professional Development, East London, South Africa.
Hyunsul JungDepartment of Medical Microbiology, University of Pretoria, South Africa.
Nicola LowInstitute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
Remco Ph PetersDepartment of Medical Microbiology, University of Pretoria, South Africa.
Jeffrey D KlausnerDepartment of Population and Public Health Sciences, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.

Funding

Clinical Study of STI Screening to Prevent Adverse Birth and Newborn OutcomesR01AI149339 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KLAUSNER, JEFFREY DAVID, MEDINA-MARINO, ANDREW · 2020 to 2024
$4.3M
NIAID NIH HHS R01 AI149339
6 · The paper itself

Abstract

Background: Methods: In a randomized three-group trial in South Africa, pregnant women aged 18 years or older were assigned before 27 weeks' gestation to: (1) screening and treatment for Findings: Of 2247 enrolled participants, 1910 had live births. The composite outcome occurred in 22·9% of the One-Time Screening group (risk ratio [RR] 0·99; 95% confidence interval [CI] 0·81-1·21), 20·6% of the Two-Time Screening group (RR 0·89; 95% CI 0·72-1·09), compared with 23·2% of the Standard-of-Care group. Preterm birth occurred in 18·9% of the One-Time Screening group (RR 1·00; 95% CI 0·80-1·26), 14·5% of the Two-Time Screening group (RR 0·77; 95% CI 0·60-0·99), and 18·8% of the Standard-of-Care group. Low birthweight occurred in 14·1% of the One-Time Screening group (RR 1·10; 95% CI 0·83-1·46), 12·9% of the Two-Time Screening group (RR 1·01; 95% CI 0·76-1·35), and 12·8% of the Standard-of-Care group. Interpretation: Neither screening strategy for

Identifiers

PMID42078373
PMCPMC13131759

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.