Evidence map›Paper›PMID 42078371›Full record

ArticlemedRxiv : the preprint server for health sciences2026

A catalogue of missense and nonsense mutation abundances for the U.S. cancer patient population.

Adith S Arun, David Liarakos, Gaurav Mendiratta, Thomas McFall, Diana C Hargreaves, Geoffrey M Wahl, Jiancheng Hu, Edward C Stites

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Adith S ArunYale School of Medicine, New Haven, CT USA.
David LiarakosIntegrative Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA.
Gaurav MendirattaIntegrative Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA.
Thomas McFallDepartment of Biochemistry, Medical College of Wisconsin, Milwaukee, WI.
Diana C HargreavesMolecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Geoffrey M WahlGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Jiancheng HuDivision of Cellular and Molecular Research, National Cancer Centre Singapore, 30 Hospital Boulevard, 168583, Singapore, Singapore.
Edward C StitesYale School of Medicine, New Haven, CT USA.

Funding

Systems Approaches for Opening Therapeutic WindowsDP2AT011327 · NCCIH · YALE UNIVERSITY · PI STITES, EDWARD C. · 2020 to 2020
$2.6M
Redefining indications of EGFR inhibitors in cancers that harbor mutant RASR01CA276771 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI Thomas Bradley McFall · 2024 to 2026
$1.8M
NCCIH NIH HHS DP2 AT011327NCI NIH HHS R01 CA276771
6 · The paper itself

Abstract

Widespread genomic sequencing efforts have characterized the molecular foundations of the different cancers. By combining these genomic data in a manner proportional to the population-level abundances of these different cancers, we estimate the overall abundances of each observed missense and nonsense mutation within the U.S. cancer patient population. We find

Identifiers

PMID42078371
PMCPMC13131743

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.