Evidence map›Paper›PMID 42078339›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Cross-ancestry evaluation of idiopathic pulmonary fibrosis genetic risk variants.

Ritah Nabunje, Beatriz Guillen-Guio, Tamara Hernandez-Beeftink, Ebrima Joof, Olivia C Leavy, International IPF Genetics Consortium, Toby M Maher, Phil Molyneux, Justin M Oldham, Imre Noth and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Ritah NabunjeDivision of Public Health and Epidemiology, University of Leicester, Leicester, UK.ORCID 0000-0001-9094-8687
Beatriz Guillen-GuioDivision of Public Health and Epidemiology, University of Leicester, Leicester, UK.
Tamara Hernandez-BeeftinkDivision of Public Health and Epidemiology, University of Leicester, Leicester, UK.
Ebrima JoofDivision of Public Health and Epidemiology, University of Leicester, Leicester, UK.
Olivia C LeavyDivision of Public Health and Epidemiology, University of Leicester, Leicester, UK.
International IPF Genetics Consortium
Toby M MaherNIHR Imperial Biomedical Research Unit, National Heart and Lung Institute, Imperial College London, London, UK.
Phil MolyneuxNIHR Imperial Biomedical Research Unit, National Heart and Lung Institute, Imperial College London, London, UK.
Justin M OldhamUniversity of Michigan, Michigan, USA.
Imre NothUniversity of Virginia, Virginia, USA.
Amaia UrrutiaServicio de Neumología, Hospital Universitario de Cruces, Barakaldo, Vizcaya, Spain; Departamento de Medicina, Universidad del País Vasco, Spain.
Myriam AburtoServicio de Neumología, Biobizkaia, Hospital Universitario de Galdakao-Usansolo, Usansolo, Vizcaya, Spain; Departamento de Medicina, Universidad del País Vasco, Spain.
Carlos FloresCentro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain.
R Gisli JenkinsNIHR Imperial Biomedical Research Unit, National Heart and Lung Institute, Imperial College London, London, UK.
Louise V WainDivision of Public Health and Epidemiology, University of Leicester, Leicester, UK.
Richard J AllenDivision of Public Health and Epidemiology, University of Leicester, Leicester, UK.

Funding

Elucidating the Genomic Determinants of Outcomes in Idiopathic Pulmonary FibrosisK23HL138190 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OLDHAM, JUSTIN M · 2017 to 2021
$914k
Derivation and validation of a clinical-molecular signature to predict fibrotic progression and treatment response in patients with autoimmune interstitial lung diseaseR56HL158935 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI OLDHAM, JUSTIN M · 2021 to 2021
$400k
NHLBI NIH HHS K23 HL138190NHLBI NIH HHS R56 HL158935Wellcome Trust
6 · The paper itself

Abstract

Genome-wide association studies of idiopathic pulmonary fibrosis (IPF) have identified 35 common genetic risk loci associated with IPF susceptibility. In this study, we evaluated the effects of the reported variants in clinically curated non-European individuals. Despite limited sample sizes, we observed partial replication, limited transferability of some variants and evidence of ancestry-specific effects. The

Identifiers

PMID42078339
PMCPMC13131758

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.