ArticleFrontiers in oral health2026
Investigating salivary growth factor responses to tooth extraction in patients with type 2 diabetes: a prospective observational comparative study.
Article in Frontiers in oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: This study aimed to evaluate salivary growth factor levels in controlled type 2 diabetic patients compared to healthy individuals, assessed at two time points: before tooth extraction and two days postoperatively. Materials and methods: The study included 27 participants: 20 with type 2 diabetes (74.07%) and 7 healthy controls (25.93%). Unstimulated whole saliva samples were collected before tooth extraction and two days afterward. Biomarker analysis was performed using a Luminex multiplex assay, targeting epidermal growth factor (EGF), transforming growth factor-alpha (TGF-α), fibroblast growth factor (FGF), platelet-derived growth factor-AB (PDGF-AB), platelet-derived growth factor-CC (PDGF-CC), and platelet-derived growth factor-DD (PDGF-DD). Results: EGF levels showed no significant differences between groups at baseline ( Conclusions: Salivary growth factors are reduced and respond differently in type 2 diabetes, potentially contributing to impaired oral wound healing. Supplementing growth factors may improve clinical outcomes, warranting further investigation.
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