Evidence map›Paper›PMID 42078317›Full record

ArticleCancer diagnosis & prognosis

Assessment of the Diagnostic Value of the UF-5000 Parameter Atyp.C in Upper Tract Urothelial Carcinoma.

Ryu Shigehisa, Satoshi Fukata, Keisuke Sugimoto, Shiori Miyazaki, Shinji Tokuhiro, Anantya Pustimbara, Chiaki Kawada, Sho Shimasaki, Erika Yamashita, Yoshitaka Kurano and 10 more

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Article in Cancer diagnosis & prognosis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

20 authors.

Ryu ShigehisaDepartment of Urology, Kochi Medical School, Kochi University, Nankoku, Japan.
Satoshi FukataDepartment of Urology, Kochi Medical School, Kochi University, Nankoku, Japan.
Keisuke SugimotoDepartment of Clinical Laboratory, Kochi Medical School, Kochi University, Nankoku, Japan.
Shiori MiyazakiDepartment of Clinical Laboratory, Kochi Medical School, Kochi University, Nankoku, Japan.
Shinji TokuhiroDepartment of Clinical Laboratory, Kochi Medical School, Kochi University, Nankoku, Japan.
Anantya PustimbaraCenter for Photodynamic Medicine, Kochi Medical School, Kochi University, Nankoku, Japan.
Chiaki KawadaDepartment of Urology, Kochi Medical School, Kochi University, Nankoku, Japan.
Sho ShimasakiDepartment of Urology, Kochi Medical School, Kochi University, Nankoku, Japan.
Erika YamashitaDepartment of Urology, Kochi Medical School, Kochi University, Nankoku, Japan.
Yoshitaka KuranoDepartment of Urology, Kochi Medical School, Kochi University, Nankoku, Japan.
Kaya AtagiDepartment of Urology, Kochi Medical School, Kochi University, Nankoku, Japan.
Daigo TakemoriDepartment of Urology, Kochi Medical School, Kochi University, Nankoku, Japan.
Shinkuro YamamotoDepartment of Urology, Kochi Medical School, Kochi University, Nankoku, Japan.
Hiroto OsakabeDepartment of Urology, Kochi Medical School, Kochi University, Nankoku, Japan.
Tomoya NaoDepartment of Urology, Kochi Medical School, Kochi University, Nankoku, Japan.
Tsutomu ShimamotoDepartment of Urology, Kochi Medical School, Kochi University, Nankoku, Japan.
Hideo FukuharaDepartment of Urology, Kochi Medical School, Kochi University, Nankoku, Japan.
Nobutaka ShimizuPelvic Floor Center, Kochi Medical School, Kochi University, Nankoku, Japan.
Shingo AshidaDepartment of Urology, Kochi Medical School, Kochi University, Nankoku, Japan.
Keiji InoueDepartment of Urology, Kochi Medical School, Kochi University, Nankoku, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/Aim: Urine cytology is widely used for diagnosing urothelial carcinoma. However, it has limited sensitivity, particularly in upper tract urothelial carcinoma. The UF-5000 automated urine analyzer includes the research parameter Atyp.C, which quantifies cells with a high nuclear-to-cytoplasmic ratio. Although it has been utilized in bladder cancer, its application has not been evaluated in upper tract urothelial carcinoma. This study compared the diagnostic performance of urine cytology versus Atyp.C and assessed the advantage of combining them. Patients and Methods: This retrospective study included 41 patients with pathologically confirmed upper tract urothelial carcinoma without concomitant bladder cancer, as confirmed via cystoscopy. The sensitivities of urine cytology (Class ≥III), Atyp.C (≥0.1), and their combined use were compared. Results: Positive findings on urine cytology were detected in 11/41 patients (26.8%) and Atyp.C was observed in 9/41 (22.0%). When either test yielded a positive result, the detection rate increased to 17/41 (41.5%). A paired comparison using McNemar's test demonstrated that the combined cytology-Atyp.C approach detected significantly more upper tract urothelial carcinoma cases than urine cytology alone (6 Conclusion: The sensitivity of Atyp.C was similar to that of urine cytology. Some patients without hydronephrosis presented with Atyp.C positivity. However, this finding may be overlooked in routine clinical practice. Although its performance is lower than that reported in bladder cancer, Atyp.C is non-invasive and does not require additional procedures. Hence, it can be clinically useful for upper tract urothelial carcinoma diagnosis. Nevertheless, to validate this notion, prospective studies should be conducted.

Indexed as

Atyp.Cdiagnostic performanceUF-5000upper tract urothelial carcinomaurine cytology

Identifiers

PMID42078317
PMCPMC13133810

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