ArticleCancer diagnosis & prognosis
Association of Early Chemotherapy With Reduced In-Hospital Mortality and Complications in Acute Promyelocytic Leukemia: Insights From a Nationwide Cohort.
Article in Cancer diagnosis & prognosis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background/Aim: Prompt treatment in acute promyelocytic leukemia (APML) is critical due to high risk of early mortality. Early initiation of chemotherapy has been associated with favorable outcomes. The purpose of this study was to investigate differences in inpatient outcomes of APML based on time to chemotherapy initiation. Patients and Methods: The National Inpatient Sample (NIS) was queried between the years 2016 and 2020 to identify all patients with APML who were administered chemotherapy inpatient. These patients were stratified into an early cohort if chemotherapy was given within 24 hours of admission and late cohort if it was after 24 hours. Baseline characteristics were compared amongst cohorts using independent sample Results: Among 5,155 APML patients, 1,300 (25.2%) received early treatment and 3,855 (74.8%) late. Early treated patients were younger (45.4±19.4 Conclusion: Early chemotherapy was associated with lower rates of DIC, sepsis and mortality despite similar demographics and comorbidity burden in APML patients. These findings support immediate initiation of chemotherapy upon presentation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.