ArticleCancer diagnosis & prognosis
A Case of Hyalinizing Clear-cell Carcinoma With
Article in Cancer diagnosis & prognosis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background/Aim: Hyalinizing clear-cell carcinoma (HCCC) is a rare malignant tumor of the minor salivary glands characterized by nests of clear cells within a hyalinized stroma. Its diagnosis remains challenging due to its histological similarity to other neoplasms, and the recent recognition of distinct molecular features, such as Ewing sarcoma breakpoint region 1 ( Case Report: A 54-year-old man presented with a painless mass on the right lateral border of the tongue. Clinical examination revealed an elastic hard tumor measuring 18×15×8 mm. Biopsy under local anesthesia revealed a malignant clear-cell neoplasm. The lesion was completely excised under general anesthesia 2 weeks later. Histopathology showed nests of clear cells with polygonal nuclei in a hyalinized stroma. Immunohistochemistry demonstrated positivity for cytokeratin AE1/AE3, p63 protein and cytokeratin 7, and negativity for cytokeratin 20, Conclusion: This case highlights the diagnostic importance of integrating histopathology, immunoprofiling, and molecular analysis in patients with rare salivary gland tumors and underscores the favorable outcomes of complete surgical resection for HCCC of the tongue.
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