ArticleCureus2026
Progressive Muscle Rigidity and Spasms in an Older Adult: A Diagnostic Challenge.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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2 authors.
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Abstract
Stiff-person syndrome (SPS) is a rare autoimmune neurologic disorder characterized by progressive rigidity, painful spasms, and heightened sensitivity to stimuli. We present the case of a 73-year-old woman initially diagnosed with immune-mediated myopathy attributed to statin use. Although her symptoms temporarily improved with corticosteroid therapy, she later developed severe rigidity and spasms triggered by touch and emotional stress, with preserved sensorium, findings that were inconsistent with typical myositis. Further evaluation revealed continuous motor unit activity on electromyography and the presence of high-titer anti-glutamic acid decarboxylase 65 (anti-GAD65) antibodies, supporting a diagnosis of SPS. This case highlights the importance of considering autoimmune neurologic disorders in patients with unexplained muscle stiffness, particularly when symptoms are stimulus-induced and unresponsive to standard therapies.
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